RA Therapy

Question 1

RA patho

Answer 1

TNF-alpha increase tissue adhesion molecules and stimulation of pro-inflammatory cytokines (IL-1, 2, and 6) and prostaglandins

Question 2

Are the mediators involved RA exogenous or endogenous?

Answer 2

Endogenous

Question 3

RA treatment

Answer 3

Entanercept (Enbrel), infliximab (Remicade), adalimumab

Question 4

Entanercept brand name

Answer 4

Enbrel

Question 5

Infliximab brand name

Answer 5

Remicade

Question 6

MoA of etanercept

Answer 6

Inhibits TNF-alpha by attaching to the TNF-alpha receptors on the T-cell to prevent the circulating TNF-alpha from attaching to the TNF-alpha receptors on the T-cell -> overall inhibiting TNF-alpha

Question 7

What are infliximab (Remicade) and adalimumab (what kind of antibodies)

Answer 7

Chimeric monoclonal antibodies

Question 8

MoA of infliximab (Remicade) and adalimumab

Answer 8

Bind to circulating TNF-alpha preventing interaction with membrane-bound TNF receptors on lymphocytes and macrophages

Can also inactivate receptor-bound TNF-alpha