Cyclosporine DI

Question 1

Cyclosporine drug class

Answer 1

Calcineurin inhibitors

Question 2

Cyclosporine MoA

Answer 2

Same as tacrolimus; halts signal 1 and prevents transcription factor in T cells

Question 3

Cyclosporine modified formulations

Answer 3

Neoral, Gengraf

Question 4

Neoral dosing

Answer 4

BID with trough monitoring

Question 5

You can dilute CYA in…

Answer 5

…apple or orange juice

Question 6

Is Gengraf bioequivalent to Neoral?

Answer 6

YES!

Question 7

Cyclosporine non-modified formulations

Answer 7

Sandimmune (PO and IV)

Question 8

Dosing frequency for PO Sandimmune

Answer 8

QD

Question 9

Is PO Sandimmune bioequivalent to modified CYA?

Answer 9

No

Question 10

Can PO Sandimmune be substituted between CYA generics?

Answer 10

No

Question 11

What can PO Sandimmune be administered with?

Answer 11

OJ or milk

Question 12

IV Sandimmune complications

Answer 12

Anaphylaxis

Question 13

IV Sandimmune stability

Answer 13

Short-term use; discard after 24 hours

Question 14

When is IV Sandimmune used?

Answer 14

In patients who can’t tolerate a PO dose

Question 15

CYA side effects

Answer 15

Hyperlipidemia, tremors, headache, nephrotoxicity, HTN