G-CSF DI Flashcards
1
Q
What does G-CSF do?
A
Stimulates proliferation of neutrophils
2
Q
G-CSF drugs
A
Filgrastim (Neupogen), Pegfilgrastim (Neulasta)
3
Q
Filgrastim brand name
A
Neupogen
4
Q
Pegfilgrastim brand name
A
Neulasta
5
Q
G-CSF MoA
A
Stimulates proliferation of neutrophils
6
Q
G-CSF drugs indication
A
Chemo-induced neutropenia, bone marrow transplantation, myelodysplastic syndrome, HIV
7
Q
G-CSF ADEs
A
Bone pain, N/V, marked leukocytosis, increased uric acid, hypersensitivity reactions
8
Q
What can be done to reduce the ADEs from G-CSFs?
A
Have a pegylated conjugate
