tablets Flashcards
it is a compressed solid dosage form containing medicaments with or without Excipients.
Tablet
Tablet is the most popular dosage form. ___ total medicines are dispensed in the form of it.
70%
These are solid, flat or biconvex dishes, unit dosage form, prepared by compressing a drug or a mixture of drugs, with or without diluents.
Tablets
Advantages of Tablets (for patients)
✓ Easy to administer
✓ Unpleasant taste can be masked
✓ Accuracy in dose
Advantages of Tablets (manufacturer)
✓ Stable
✓ Economical
✓ Easiest and Cheapest to package and ship
Disadvantages of Tablets
• Challenging for children and unconscious patients.
• Compression problems with crystalline drugs.
• Unsuitable for hygroscopic drugs.
• Difficulties with slow-dissolving drugs.
• Added costs for taste masking through coating/encapsulation.
General Properties of Tablet Dosage Form
Defect-free and elegant.
Withstand shocks.
Maintain physical and chemical integrity.
Consistent medicinal agent release.
Types of Tablets
• Tablets ingested orally
• Tablets used in the oral cavities
• Tablets administered by other routes
• Tablets used to prepare solutions
Formed by compression and contain no special coating. It provides rapid disintegration in gastric fluid after ingestion, allowing for quick absorption of the dosage form.
Ex: Paracetamol & Aspirin
Compressed Tablet
Tablets made by more than one compression cycle.
Multiple Compressed Tablets
It is meant for administration by swallowing and are designed to by-pass the stomach and get disintegrated in the intestine only.
Ex: Bisacodyl tablet
Enteric coated Tablets
Containing a sugar coating. These are done to mask the bitter and unpleasant odour and the taste of the medicament.
Ex: Ascorbic Acid (Poten-Cee)
Sugar coated Tablets
Tablet that has a film coating of some polymer substance, such as hydroxy propyl cellulose. This protects the medicament from atmospheric effects.
Ex: Sildenafil (Viagra)
Film coated tablets
Tablets which are required to be broken and chewed in between the teeth before ingestion. These tablets should have very acceptable taste and flavour.
Ex: Simeticone (Restime)
Chewable tablets
Release the drug at a desired time and prolong the effect of the medicament.
This release the medicament in a sufficient quantity and as when required to maintain the maximum effective concentration of the drug in the blood throughout the period of treatment.
Ex: Diclofenac SR
Sustained action tablets
Tablets Ingested Orally
• Compressed Tablet
• Multiple Compressed Tablet
• Enteric Coated Tablet
• Sugar Coated Tablet
• Film Coated Tablet
• Chewable Tablet
• Sustained Action Tablet
Placed between the gum & cheek. This dissolves slowly & absorb directly.
Ex: Progesterone
Buccal Tablet
Placed under the tongue. This dissolves quickly and absorbed directly without passing into GIT
Ex: Nitroglycerin
Sublingual Tablet
This is designed to exert a local mouth or throat.
Ex: Strepsils
Lozenges
These are minor compressed tablet meant for placing them in the empty socket after tooth extraction. These cones enerally get dissolved in 20-40 minutes time
Ex. Advil
Dental Cones
Tablets Used in the Oral Cavities
• Buccal Tablet
• Sublingual Tablet
• Lozenges
• Dental Cone
This tablet placed below the skin or subcutaneouslyby means of a minor surgical operation and are slowly absorbed.
Ex: Prodetoxon
Implantation Tablet
This tablet are meant to dissolve slowly in vaginal cavity.
Ex: Clotrimaxole
Vaginal Tablet
Tablets Administered in Other Routes
Implantation Tablet
Vaginal Tablet
This is meant to add in water. They dissolved rapidly in water due to the chemical reaction which takes place between alkali bicarbonate and citric acid.
Ex: Ranitidine (Histac)
Effervescent Tablet
This is intended to a given volume of water to produce a solution of a given concentration.
Ex: Enzyme tablet (Digiplex)
Dispensing Tablet
This is a compressed tablet that contains one or more dugs. It is dissolved in sterile water and administered parenterally.
Hypodermic Tablet
These are small cylindrical, moulded or compressed tablet which contains a potent medication with a diluent.
Ex: Enzyme tablet (Digiplex)
Tablet Triturates
Tablets Used to Prepare Solutions
• Effervescent Tablet
• Dispensing Tablet
• Hypodermic Tablet
• Tablet Triturates
- Fillers used to make the required bulk of the tablet
- Provide better tablet properties such as improved cohesion
Diluent