lab pf Flashcards
Friabilator internal diameter
283-291mm
Friabilator Depth-between ___, of transparent synthetic polymer with polished internal surfaces, and subject to minimum static build up.
36-40 mm
the tablets are tumbled at each turn of the drum by a curved projection with an inside radius between ___ and ___ mm that extends from the middle of the drum to the outer wall.
75.5
85.5
Friabilator
• outer diameter of central ring - between ____
24.5 and 25.5 mm
Friabilator
• the drum is attached to the horizontal axis of a device that rotates __ rpm.
• Each tablet turn the tablets roll or slide and fall onto the drum wall or onto each other.
25 +- 1
Friability test procedure is generally applicable to most compressed tablets. Measurement of tablet friability supplements other physical strength measurements, such as tablet breaking force. This tablets must be hard enough to withstand mechanical stress during packaging, shipment and handling by the consumer.
For tablets with a unit weight equal or less than 650 mg, take a sample of whole tablets corresponding as near as possible to __. For tablets with units more than 650 mg, take a sample of ___
6.5g
10 whole tablet
In friability testing, how long is the drum rotated?
100 times (100rpm or 25 rpm for 4 times)
In Friability: Generally the test is run once. If obviously craked, cleaved, or broken tablets are present after
tumbling - the tablets ___
failed
If the results are difficult to interpret or weight loss is greater than the exected value - test is repeated __ and __ of the 3 tests is determined
twice
mean
A maximum mean weight loss from the 3 samples of ___ is considered acceptable in most products
not more than 1.0%
Ordinary Compressed Tablets hardness range
4-10kg
Sublingual tablets hardness range
2kg
Chewable tablets hardness range
3kg
Buccal tablets hardness range
10kg
