T7: SLE and Myofascial Pain Syndrome and Fibromyalgia Flashcards
Systemic Lupus Erythematosus
chronic autoimmune inflammatory disease of collagen in skin, joints, and internal organs
SLE affects
skin, joints, serous membranes (pleura, pericardium), renal system, hematologic system, neurologic system
SLE clinical manifestations: dermatologic
-Vascular skin lesions (Most commonly in sun-exposed areas)
-Butterfly rash
-Discoid lesions (round-coin shaped lesions)
-Subacute cutaneous lupus
-Oral/nasopharyngeal ulcers
-Alopecia
SLE clinical manifestations: musculoskeletal
-Polyarthralgia with morning stiffness
-Arthritis
-Swan neck fingers
-Ulnar deviation
-Subluxation with hyperlaxity of joints
-Increased risk of bone loss and fracture
SLE clinical manifestations: cardiopulmonary
-Tachypnea
-Cough
-Pleurisy
-Dysrhythmias (Fibrosis of SA and AV nodes)
-Pericarditis
-Antiphospholipid syndrome-hypercoaguability (MI, stroke, gangrenous lesions due to emboli)
SLE clinical manifestations: renal
-Mild proteinuria to rapidly progressive glomerulonephritis
-Scarring, permanent damage can lead to end-stage renal disease-leading cause of death
treatments for SLE
-Corticosteroids-prednisone, methylprednisolone
-cytotoxic agents-Cytoxan
-immunosuppressive agents-Imuran, cyclosporine, CellCept
immunosuppressive drug fro SLE
methotrexate
SLE clinical manifestations: nervous system
-Generalized/focal seizures
-Peripheral neuropathy
-Cognitive dysfunction (Disordered thinking, Disorientation, Memory deficits)
SLE clinical manifestations: hematomogic
-Formation of antibodies against blood cells
-Anemia
-Leukopenia
-Thrombocytopenia
-Coagulation disorder
SLE clinical manifestations: infection
-Increased susceptibility to infections
-Defects in ability to phagocytize invading bacteria
-Deficiency production of antibodies
-Immunosuppressive effect of many antiinflammatory drugs
-Infection is a major cause of death
diagnostics for SLE
really hard to diagnose
-Anti-nucleic antibody (ANA)
-ANA is present in 97% of persons with the disease
-Anti-DNA 50%
-Anti-Sm(Smith) 30-40%
-ESR, CRP (only used for monitoring not diagnosis)
care for SLE
*managing the disease while preventing complications of treatments.
drug therapy for SLE
-NSAIDs (Mild arthralgia or arthritis)
-Antimalarial drugs
-Steroid-sparing drugs
-Corticosteroids (Severe cutaneous SLE)
-Immunosuppressive drugs (Methotrexate, azathioprine, cyclophosphamide)
in SLE observe for
-Fever pattern
-Joint inflammation
-Limitation of motion
-Location and degree of discomfort
-Fatigue