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Physiology of Reproduction > T4: Maternal Recognition > Flashcards

T4: Maternal Recognition Flashcards

1
Q

What Is MRP

A

biochemical signal that prevents luteolysis, results in the maintenance of pregnancy

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2
Q

what does the conceptus present graph look like

A

during the critical period, the conceptus “notifies” the dam of its presence. Progesterone is maintained and sustained the entire time-horizontal

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3
Q

what is luteotrophic

A

-functioning to increase the lifespan of the CL
-usually acts directly on the CL
-gonadotropin=LH
-stimulates growth

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4
Q

what is Antiluteolytic

A

-functioning to prevent luteolysis by blocking the luteolytic factor
-inhibition of PGF2a

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5
Q

what is the cow/eww MRP

A

-Embryo produces interferon-tau
-antiluteolytic
-produced by trophoblast cells between D10-21 pregnancy

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6
Q

how does cow/eww MRP work

A

-IFN-T released from trophoblast
-binds to endometrium
-blocks oxytocin receptor synthesis = decrease in PGF2a
-binds to apical portion of uterine glands
-protein released and help embryo growth

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7
Q

describe what happens in non pregnant cows/ewe normally

A

-PGF2a produced by ?? acts on corpus luteum
-corpus luteum releases oxytocin
-progesterone is inhibited and luteolysis is maintained

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8
Q

what is the lone antiluteolytic factor of MRP in sheep

A

INF-T

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9
Q

when is IFNT produced in regards to the luteolytic mechanism begins

A

IFN-t is produced before luteolytic mechanism begins

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10
Q

when does IFNT production start

A

about day 10

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11
Q

when does luteolytic mechanism occur

A

about day 14-16

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12
Q

describe the sow’s MRP

A

-conceptus produces estrogen
-two conceptuses/ horn required
-no conceptuses in one horn= PGF2a (endocrone)= luteolysis

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13
Q

describe the hormones used in sows MRP

A

-PGF2a secreted toward uterine lumen (exocrine), not circulation
-Estrogen (+) uterine contractility, helps distribute conceptuses to both horns

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14
Q

describe the mare MRP capsule

A
  • proteins/ estrogen
    -conceptus presence prevents luteolysis = endometrial PGF2a production decreases
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15
Q

describe mare MRP motility

A

-movement of the conceptus is important(must migrate 12-14x on days 12,13,14
-the presence of the egg is the recognition factor: touching the walls of the endometrium
-restriction of movement results in pregnancy failure

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16
Q

what type of factor is involved in mare MRPS

A

unknown anti-luteolytic factor that inhibits PGF2a

17
Q

describe human MRP

A

-hCG
-luteotrophic hormone
-LH-like activity
–binds to LH receptor in CL
–maintains life of CL and P4 production
-production peaks 9-14 weeks of pregnancy
–CL loses function
–switch to placental production

18
Q

what signal is needed for a bitch or queen

A

no signal from conceptus is necessary

dog: diestrus length similar to gestation length (CL maintained)
cat: mating induced CL formed; luteal duration same as gestation

19
Q

what is the summary of the bitch/queen

A

no pregnancy recognition factor, no critical period for recognition/ time of attachment

20
Q

what is the summary for the cow

A

-bIFN-t (BTP-1) is the MRP
-critical period: 15-16 dats
-time of attachment: 18-22
-antiluteolytic

21
Q

what is the summary for ewe

A

-oIFN-t(otp-1) is the MRP
-critical period: 13-14
-time of attachment: 15-18
-antiluteolytic

22
Q

what is the summary for the mare

A

-3 proteins/ estrogen= ?
-critical period: 12-14
-attachment: 36-38
-unknow anti- luteolytic

23
Q

what is the summary of the sow

A

-estrogen is the MRP
-critical period: 11-12
-attachment: 14-18
????

24
Q

what is the summary for humans

A

-hCG is the MRP
-critical period: 7-12 days
-attachment: 9-12
-luteotropic hormone

25
Q

what is the most important factor that needs to happen for pregnancy

A

maternal recognition of pregnancy must occur prior to luteolysis

26
Q

what structure in the cow and ewe secretes materials that block the synthesis of uterine oxytocin receptors

A

blastocysts

27
Q

what in the sow reroutes PGF2a secreted by the endometrium

A

estrogen

28
Q

describe the MRP for sows

A

-conceptus produced estrogen that serves as the signal for MRP
-PGF2a is produced in large quantities but is rerouted into uterine lumen

29
Q

how does the rerouting of PGF2a work in sows

A

-directed to be secreted away from the capillaries and toward the uterine lumen
-luminal PGF2a can’t cause luteolysis
-estrogen increases receptor production for prolactin in the endometrium
-promotes exocrine secretion of PGF2a to the uterine lumen rather than endocrine

30
Q

what is another important feature for sow MRP

A

there must be at least two conceptuses present in each uterine horn for pregnancy to be maintained

Physiology of Reproduction (22 decks)

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