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QUIZ 15 > T Cells III > Flashcards

T Cells III Flashcards

1
Q

stimuli that activate T cells

A

MHC/peptide + co-stim, mitogens, agonist antibodies, chemical mediators, superantigens

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2
Q

MHC/peptide + co-stimulatory signal

A

TCR + CD28, TCR+CD40L

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3
Q

mitogens

A

PHA, conA (non-specific activation for proliferation)

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4
Q

agonist antibodies

A

anti CD3 + anti CD28, anti TCR + anti CD28

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5
Q

chemical mediators

A

PMA + calcium ionophores

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6
Q

T cell activation (proliferation)

A

requires 2 competence signals and 1 progression signal (3 total)

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7
Q

competence signals

A

TCR engagement and then a co-stimulatory signal

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8
Q

progression signal

A

IL-1, IL-4, IL-6, IL-12, TGF-beta

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9
Q

3 signals cause _

A

activation –> survival –> differentiation

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10
Q

activation

A

MHC-TCR binding

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11
Q

survival

A

B7-CD28 binding (B7=CD80)

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12
Q

differentiation

A

IL-6, IL-12, IL-4, TGF-beta (cytokines)

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13
Q

CD28 vs CTLA-4

A

CD28 is on naive T cells and CTLA-4 is after activation

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14
Q

CTLA-4

A

down-regulation; higher affinity for CD80

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15
Q

CD28

A

proliferation and differentiation

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16
Q

cytokine for Th1

A

IL-12

17
Q

Th1 releases

A

IFN-gamma

18
Q

cytokine for Th2

A

IL-4

19
Q

Th2 releases

A

IL-4, IL-5, IL-13

20
Q

cytokine for Th17

A

IL-6, IL-1b, TGF-beta

21
Q

Th17 releases

A

IL-17, IL-21

22
Q

cytokine for Treg

A

TGF-beta

23
Q

Treg releases

A

TGF-beta and IL-10

24
Q

cytokine for Tfh

A

IL-6, IL-21

25
Q

Tfh releases

A

IL-21

26
Q

Th1

A

classic immune response; releases IFN-gamma to stimulate macrophages

27
Q

Th2

A

releases IL-4, IL-5, IL-13 to activate eosinophils and mast cells and cause IgE switch in response to parasites

28
Q

Th17

A

releases IL-17 and mainly activates neutrophils

29
Q

Tfh

A

provides help for B cells

30
Q

Treg

A

regulates cells by inhibiting activation

31
Q

TH1 effects of macrophage activation

A

increase MHC-II, increase TNF receptors, increase radicals, increase nitric oxide

32
Q

B cell help by _

A

Th1, Th2, and mostly Tfh

33
Q

Treg cells are characterized by _

A

CD4, CD25 expression

34
Q

What is needed to stimulate CD8+?

A

4-IBBL

35
Q

proteins in lytic granules of CD8+

A

perforin and granzymes

36
Q

perforin

A

polymerizes to form a pore in target membrane

37
Q

granzymes

A

serine proteases, which activate apoptosis once in cytoplasm of target cell

QUIZ 15 (16 decks)

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