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QUIZ 15 > extra > Flashcards

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1
Q

effector memory T cell markers

A

CD45RO; no CCR7 or L-selectin

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2
Q

central memory T cell markers

A

CD45RO, CCR7, L-selectin, and CD44

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3
Q

naive T cell markers

A

CD45RA, CCR7, L-selectin

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4
Q

myeloid cell markers

A

no CCR7 or L-selectin

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5
Q

CD8+ cells

A

kill virus-infected cells

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6
Q

CD4+ Th1 cells

A

activate infected macrophages and help B cells; for listeria or mycobacteria

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7
Q

CD4+ Th2 cells

A

switch B cells to IgE by releasing IL-4; for parasites

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8
Q

CD4+ Th17 cells

A

recruit neutrophils and barrier integrity; for fungi and pneumonia

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9
Q

CD4+ Tfh cells

A

antibody production

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10
Q

CD4+ Treg cells

A

suppress T cells

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11
Q

CD45RA

A

naive T cells

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12
Q

CD45RO

A

memory marker

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13
Q

ICAM-1,2,3

A

on endothelial cells; binds LFA-1 and Mac-1 for adhesion

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14
Q

VCAM-1

A

on endothelial cells; binds VLA-4 for adhesion

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15
Q

L-selectin

A

on naive T cells and promotes migration into HEVs by binding PNAds

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16
Q

PNAds

A

GlyCAM-1, CD34 for slow rolling

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17
Q

P & E-selectins

A

on non-lymphoid tissue (bind core-2 glycans)

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18
Q

CCR9

A

gut specific T cell chemokine receptor

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19
Q

CCR7

A

T cell chemokine receptor

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20
Q

CCL19/CCL21

A

chemokines that bind CCR7

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21
Q

MadCAM-1/a4b7

A

bind L-selectin in gut

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22
Q

CXCR4/CXCL12

A

diapedesis

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23
Q

IL-1

A

most potent, part of acute phase response and lymphocyte activating factor; released by macrophages

24
Q

IL-3

A

maintains stem cells and progenitors and induces proliferation; released by Th1 and Th2 cells

25
Q

IL-4

A

makes Th2 for IgE production; released by basophils

26
Q

IL-5

A

eosinophil generation; IgA class switch

27
Q

IL-6

A

metabolism, heat generation; makes Th17 and Tfh

28
Q

IL-7

A

induces lymphoid lineage

29
Q

IL-8

A

attracts neutrophils; angiogenic factor

30
Q

IL-10

A

resolution

31
Q

IL-12

A

enhances production of IFN-gamma by NK cells and T cells; Th1 induction

32
Q

IL-15

A

makes NK cells

33
Q

IL-17

A

recruits PMNs

34
Q

IL-23

A

stimulate Th17

35
Q

IL-21

A

stimulate Th17; cell proliferation

36
Q

TNF-alpha

A

vessel permeability

37
Q

type I IFN

38
Q

TGF-beta

A

makes Treg

39
Q

innate response to virus

A

virus –> NK cells/pDCs –> type I IFN –> DCs –> CD8+ –> IFN-gamma –> IgG

40
Q

innate response to IC bacteria

A

macrophages –> IL-12 –> DCs –> Th1 –> IFN-gamma –> IgG

41
Q

innate response to EC bacteria/fungi

A

macrophages/neutrophils –> IL-23 –> DCs –> Th17 –> IL-17 –> IgG/IgA

42
Q

innate response to parasites

A

eosinophils/basophils –> IL-4 –> DCs –> Th2 –> IL-4 –> IgE

43
Q

type I hypersensitivity

A

IgE-mediated response to allergies

44
Q

type II hypersensitivity

A

IgM or IgG-mediated response to self-antigens

45
Q

type III hypersensitivity

A

IgG-mediated response to antigen-antibody complex (serum sickness)

46
Q

type IV hypersensitivity

A

cell-mediated dermatitis from Th1 macrophage activation

47
Q

CD4 releases _ for Th1 stimulation

48
Q

CD4 releases _ for Th2 stimulation

49
Q

CD4 releases _ for Th17 stimulation

A

IL-1, IL-6, IL-21

50
Q

CD4 releases _ for Treg stimulation

51
Q

CD4 releases _ for Tfh stimulation

A

IL-6, IL-21

52
Q

Th1 releases _

53
Q

Th2 releases _

54
Q

Th17 releases _

55
Q

Treg releases _

56
Q

Tfh releases _

QUIZ 15 (16 decks)

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