Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

QUIZ 15 > Immune Stimulation > Flashcards

Immune Stimulation Flashcards

1
Q

conditions where immune modulation is the goal

A

immune deficiency, chronic infection, chemo, immunological disorders (MS), cancer, myelogenous blood disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

antigen specific modulators

A

active and passive immunization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

non-antigen specific modulators

A

adjuvants (BCG, cytokines, alum, liposomes), macrophage activation, cytokines (IL-2, IFNs), passive immunoglobulins (monoclonal Abs), and drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

filgrastim

A

G-CSF stimulating factor (neutrophils); used for neutropenia or in conjunction with chemotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

filgrastim dosing

A

injectable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

filgrastim side effects

A

fever, cough, bone pain, reactions at injection site; severe effects are splenic rupture, sickle cell crisis, acute respiratory distress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

IFN-alpha2a, 2b (type I IFNs)

A

help with viral infections like hepatitis C; recombinant human proteins that are administered weekly (IM or subQ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

type I IFN mechanism

A

act by inducing IFN-sensitive genes with different antiviral activities, direct effect on viral replication, indirectly elicits T cell response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

type I IFN side effects

A

injection site reaction, flu-like symptoms, depression, breathing problems, leukopenia, neutropenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

epoetin alpha

A

EPO; can be used for anemia; increases level of RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

epoetin alpha dosing

A

injected 3 times weekly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

epoetin alpha side effects

A

hypertension, headaches, thrombotic events, sensitivity reactions, stroke, death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

contraindications for epoetin alpha

A

bone-marrow based cancers and acute myelogenous leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

aldesleukin (IL-2)

A

immunostimulant that can be used in cases of metastasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

IL-2 mechanism

A

recombinant human IL-2; must be closely managed during and post IV infusion; induces proliferation of T cells and enhances effector functions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IL-2 side effects

A

flu-like symptoms, hypotension, drowsiness, vascular/capillary leak syndrome, pulmonary brain edema

17
Q

sargramostim

A

GM-CSF for macrophages and neutrophils via STAT pathway

18
Q

sargramostim side effects

A

infusion site reactions, hypotension, tachycardia, joint pain, headaches, hair loss, edema, shortness of breath, thrombocytopenia

19
Q

sargramostim warnings

A

fluid retention with respiratory, cardio, renal, and hepatic symptoms

20
Q

IFN-beta1

A

relapsing-remitting MS; avonex, betaseron

21
Q

IFN-beta1 dosing

A

subQ every other day

22
Q

IFN-beta1 mechanism

A

acts via IFN receptors to regulate expression of antiviral genes and immune enhancing genes including for cytokines and MHC antigens

23
Q

IFN-beta1 side effects

A

flu-like symptoms, depression, rash, anaphylaxis

24
Q

lenalidomide/thalidomide

A

affect cytokine release

25
Q

lenalidomide uses

A

multiple myeloma, myelodysplastic disorders with del(5q)

26
Q

lenalidomide side effects

A

diarrhea, rash, fatigue, leukopenia, thrombocytopenia, blood clots, liver toxicity

27
Q

thalidomide uses

A

multiple myeloma, erythema nodosum leprosum

28
Q

thalidomide side effects

A

teratogen, drowsiness, nerve damage, birth defects

29
Q

bacillus-calmette guerin

A

live attenuated vaccine derived from mycobacterium bovis used for TB vaccine in other countries and invasive bladder cancer

30
Q

bacillus-calmette guerin side effects

A

granulomatous lesions at sites, swollen lymph nodes

31
Q

Rho(D) immune globulin

A

passively blocks immune system from recognizing Rh differences; used to treat Rh antigen incompatibility

32
Q

Rho(D) immune globulin side effects

A

fever, headaches, pain at site, erythrocyte breakdown

33
Q

immediate drug allergy (type I)

A

vasoactive mediators; IgE-mediated acute allergic reactions causing mast cell degranulation

34
Q

autoimmune reaction (type II)

A

cell destruction; IgG or IgM response to modified host proteins (from drug) which causes cell lysis or Ab-toxicity

35
Q

examples of type II reactions

A

lupus from hydralazine, hemolytic anemia from methyldopa, or thrombocytopenia purpura from quinidine

36
Q

serum sickness (type III)

A

complement deposition; immune complexes containing IgG and is a multisystem complement-dependent vasculitis due to Ab’s against the drug; arthritis, fever, lymph nodes swollen

37
Q

examples of serum sickness

A

sulfonamides, thiouracil, anticonvulsants, antibody therapeutics

38
Q

cell-mediated reactions (type IV)

A

contact dermatitis from topically-applied drugs

QUIZ 15 (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions