Phagocytosis

Question 1

phagocytic cells

Answer 1

monocytes, macrophages, neutrophils, DC’s

Question 2

APC phagocytic cells

Answer 2

DC’s and macrophages

Question 3

phagocytic receptors

Answer 3

mannose receptor, LPS receptor (CD14), TLR’s, CD11b/CD18 (CR3), FcR

Question 4

opsonin

Answer 4

molecule that acts as a binding enhancer for the process of phagocytosis

Question 5

TLR3

Answer 5

recognizes dsRNA from viruses

Question 6

TLR4

Answer 6

recognizes LPS

Question 7

listeria moocytogenes

Answer 7

can escape into cytoplasm in unactivated macrophages but IFN-gamma will prevent its escape

Question 8

leukocyte adhesion deficiency

Answer 8

defective CD18 causes defective migration of phagocytes into infected tissues causing widespread infections with capsulated bacteria

Question 9

chronic granulomatous disease

Answer 9

defective NADPH oxidase prevents phagocytes from producing superoxide anion and killing bacteria leading to chronic infections and granulomas

Question 10

G6PD deficiency

Answer 10

defective respiratory burst impairs killing of bacteria causing chronic infections and sometimes anemia

Question 11

MPO deficiency

Answer 11

impairs killing of bacteria causing chronic infections

Question 12

Chediak-Higashi syndrome

Answer 12

defect in vesicle fusion causes impaired phagocytosis leading to recurrent bacterial infections and granulomas