Hematopoiesis Flashcards
defining property of stem cells
self-renewal
multipotent stem cells
can give rise to multiple types of differentiated progeny cells
unipotent stem cells
can give rise to only one type of differentiated progeny cells
induced pluripotent stem cells
de-differentiate skin fibroblasts –> induce pluripotency –> differentiation into desired cell type
blood stem cells can _
self-renew, become platelets, WBC’s, and RBC’s
development of mature cells
stem cells –> progenitor cells –> precursor cells –> mature cells
stem cell properties
high self-renewal, low proliferation, high potential (can become anything)
progenitor cell properties
not much self-renewal, some proliferation, high potential
precursor cell properties
no self-renewal, high proliferation, one potential
mature cell properties
no self-renewal, some proliferation, one potential
pluripotent hematopoietic stem cell gives rise to _
common lymphoid and common myeloid progenitors
common lymphoid progenitors give rise to _
B cell, T cell, and NK cells in the blood
common myeloid progenitors give rise to _
granulocyte/macrophage progenitors and megakaryocyte/erythrocyte progenitors
erythrocyte progenitors give rise to _
platelets and erythrocytes
granulocyte/macrophage progenitors give rise to _
neutrophils, eosinophils, basophils, mast cell precursor, monocytes (in blood)
dendritic cells come from _
both myeloid and lymphoid progenitors
IL-3
produced by T cells (Th1 and Th2) and binds to the IL-3 receptor to maintain stem cells and early progenitors; induces proliferation but not differentiation
stem cell factor
produced by stromal cell and binds to c-kit to maintain stem cells and early progenitors; induces proliferation but not differentiation
IL-7
predisposes progenitors toward lymphoid development
EPO
red blood cell development
thrombopoietin (TPO)
needed for megakaryocyte development and platelet formation
granulocyte/macrophage colony stimulating factor (GM-CSF)
works on common granulocyte/macrophage precursor; stimulates growth and differentiation of monocytes and neutrophils
granulocyte colony stimulating factor (G-CSF)
works on granulocyte-committed progenitors; stimulates growth and differentiation of neutrophils
monocyte/macrophage colony stimulating factor (M-CSF)
works on monocyte/macrophage progenitors; stimulates growth and differentiation of monocytes
agranulocytes
monocytes and lymphocytes
granulocytes
neutrophils, eosinophils, basophils
