T & B Cells Flashcards
Type of immune cell that uses perforin and granzymes to kill virus-infected or tumor cells
Natural Killer (NK) cell
Cytokines that enhance NK cell activity
IL-2, IL-12, IFN-α, IFN-β
NK cells are induced to kill when lacking this MHC signal on target cell
MHC I
NK cells also kill via this mechanism involving CD16 and IgG
Antibody-dependent cell-mediated cytotoxicity
Type of immunity B cells mediate
Humoral immunity
Type of immunity T cells mediate
Cell-mediated immunity
T cells that help activate B cells and other leukocytes
CD4+ T cells
T cells that directly kill infected cells using perforin and granzyme
CD8+ T cells
B cells differentiate into these antibody-secreting cells
Plasma cells
T cell rule of 8 for MHC interaction
MHC II × CD4 = 8; MHC I × CD8 = 8
Location where positive selection of T cells occurs
Thymic cortex
Location where negative selection of T cells occurs
Thymic medulla
Function of Th1 cells
Activate macrophages and cytotoxic T cells
Function of Th2 cells
Activate eosinophils and promote IgE production
Function of Th17 cells
Induce neutrophilic inflammation
Function of Treg cells
Suppress immune response and maintain tolerance
Region of antibody that determines antigen specificity
Fab region
Region of antibody that binds complement and Fc receptors
Fc region
3 key antibody functions: neutralization, opsonization, and…
Complement activation
Most abundant antibody in serum, crosses placenta
IgG
Antibody found in secretions and mucosal membranes
IgA
First antibody produced in primary response, pentameric
IgM
Antibody expressed on naive B cells; function unclear
IgD
Antibody that mediates type I hypersensitivity and parasite defense
IgE
Antigens that lack protein, poorly immunogenic, no memory
Thymus-independent antigens
Antigens that involve protein and generate memory via Th cells
Thymus-dependent antigens
