Complement

Question 1

Complement pathway activated by antigen-antibody complexes (IgG or IgM)

Answer 1

Classical pathway

Question 2

Complement pathway activated by microbe surface molecules

Answer 2

Alternative pathway

Question 3

Complement pathway activated by mannose or sugars on microbes

Answer 3

Lectin pathway

Question 4

Complement protein involved in opsonization

Answer 4

C3b

Question 5

Complement proteins involved in anaphylaxis

Answer 5

C3a, C4a, C5a

Question 6

Complement protein involved in neutrophil chemotaxis

Answer 6

C5a

Question 7

Complement complex responsible for cytolysis

Answer 7

MAC (C5b-9)

Question 8

Two main opsonins in bacterial defense

Answer 8

C3b and IgG

Question 9

Proteins that prevent complement activation on self cells

Answer 9

DAF (CD55) and C1 esterase inhibitor

Question 10

Deficiency of early complement proteins (C1-C4) increases risk of

Answer 10

SLE and recurrent infections

Question 11

Deficiency of terminal complement proteins (C5-C9) increases susceptibility to

Answer 11

Neisseria infections

Question 12

Deficiency causing hereditary angioedema due to ↑ bradykinin

Answer 12

C1 esterase inhibitor deficiency

Question 13

Disorder caused by impaired GPI anchor synthesis, leading to complement-mediated lysis of RBCs

Answer 13

Paroxysmal nocturnal hemoglobinuria

Question 14

Complement pathway activated by antigen-antibody complexes (IgG or IgM)

Answer 14

Classical pathway

Question 15

Complement pathway activated by microbe surface molecules

Answer 15

Alternative pathway

Question 16

Complement pathway activated by mannose or sugars on microbes

Answer 16

Lectin pathway

Question 17

Complement protein involved in opsonization

Answer 17

C3b

Question 18

Complement proteins involved in anaphylaxis

Answer 18

C3a, C4a, C5a

Question 19

Complement protein involved in neutrophil chemotaxis

Answer 19

C5a

Question 20

Complement complex responsible for cytolysis

Answer 20

MAC (C5b-9)

Question 21

Two main opsonins in bacterial defense

Answer 21

C3b and IgG

Question 22

Proteins that prevent complement activation on self cells

Answer 22

DAF (CD55) and C1 esterase inhibitor

Question 23

Deficiency of early complement proteins (C1-C4) increases risk of

Answer 23

SLE and recurrent infections

Question 24

Deficiency of terminal complement proteins (C5-C9) increases susceptibility to

Answer 24

Neisseria infections

Question 25

Deficiency causing hereditary angioedema due to ↑ bradykinin

Answer 25

C1 esterase inhibitor deficiency

Question 26

Disorder caused by impaired GPI anchor synthesis, leading to complement-mediated lysis of RBCs

Answer 26

Paroxysmal nocturnal hemoglobinuria