MHC -HLA

Question 1

Organs where immune responses are limited to avoid inflammatory damage (e.g., eye, brain, placenta, testes)

Answer 1

Immune privilege

Question 2

MHC class encoded by HLA-A, HLA-B, HLA-C

Answer 2

MHC I

Question 3

MHC class encoded by HLA-DP, HLA-DQ, HLA-DR

Answer 3

MHC II

Question 4

MHC I binds to this type of T cell receptor and coreceptor

Answer 4

TCR and CD8

Question 5

MHC II binds to this type of T cell receptor and coreceptor

Answer 5

TCR and CD4

Question 6

MHC I is expressed on all nucleated cells and platelets except

Answer 6

RBCs

Question 7

MHC II is expressed only on these cells

Answer 7

APCs

Question 8

Presents endogenous antigens to CD8+ T cells

Answer 8

MHC I

Question 9

Presents exogenous antigens to CD4+ T cells

Answer 9

MHC II

Question 10

MHC I antigen loading occurs here with help of TAP

Answer 10

RER

Question 11

MHC II antigen loading occurs here after release of invariant chain

Answer 11

Acidified endosome

Question 12

Associated protein with MHC I

Answer 12

β2-microglobulin

Question 13

Associated protein with MHC II

Answer 13

Invariant chain

Question 14

Structure of MHC I chains

Answer 14

1 long chain, 1 short chain

Question 15

Structure of MHC II chains

Answer 15

2 equal-length chains (2 α, 2 β)