Systems Flashcards
What is essential to immunity?
The capacity to recognize foreign invaders (non-self)
What problems arise with recognizing foreign invaders?
When the bodies response to a foreign invader is to excessive or when your own healthy tissue is perceived as foreign or dangerous
When the bodies response to a foreign invader is to excessive its usually due to?
Allergies
Hypersensitivity
when your own healthy tissue is perceived as foreign or dangerous it can be due to an?
Autoimmunity
What is a microbe?
Bacteria, Viruses
What is an antimicrobial substance?
It tends to kill or damage microbes - eg lysosomal enzymes released by immune cells
What is an antigen?
Large molecules (usually proteins or polysaccharides that elicit specific responses from hosts)
What is an epitope?
A specific discrete component of an antigen that attract immune response
What are the two responses of the immune system?
Innate and Adaptive
Define an innate immune response?
A general response. It is the first line of defense. We are born with it.
What are some examples of innate immune response?
Skin/ Mucous Membrane
Inflammation/ Fever
Stimulates adaptive responses
What is an example of first line defense?
Skin Mucous membrane
What is an example of a second line of defense?
Antimicrobial substances, and natural killer cells and phagocytes,
What are the primary cells for adaptive immunity?
B lymphocytes
T Lymphocytes
What are accessory cells?
They are phagocytes (macrophages, neutrophils, eosinophils) that kill or break apart an invader.
What do dendritic cells do?
Presents antigens/ epitopes to killers
What humoral immunity?
In blood and lymph there are a high number of immune cells and other immune materials.
How are B Cells a key player in humoral immunity?
Great at recognizing microbes and antigens
What happens when a b cell is activated?
It selects the type of clone needed.
What is a b cell called when it reaches full maturation?
Plasma cell
What do antibodies bind to and what happens when this happens?
Bind to epitopes and either kill/neutralize the invader, or present them to t cells or macrophages
Can some B cells become memory cells?
Yes
What are memory cells and what do they do?
They stay in the body to respond quickly if a secondary exposure to the same antigen occurs
What are the five types of antibodies?
IgG IgA IgM IgD IgE
What antibody makes up 70 to 80% of all antibodies in the body?
IgG
What is the only type of antibody that crosses the placenta?
IgG
Where does IgG diffuse from in the body?
Diffuses readily out of the vascular zone into the tissues
What are the actions of IgG?
Antiviral, antitoxin, antibacterial actions
What antibody activates killer cells?
IgG
What antibody activates the compliment system?
IgG
Which antibody is predominantly found in saliva, tears, nasal and respiratory secretions?
IgA
What antibody is found in breast milk?
IgA
What does the antibody IgA block entry to?
Blocks entry of organisms to the eyes, gut, respiratory and urinary tracts
What antibody remains within blood and lymph?
IgM
What antibody is considered an early responder?
IgM
What is the first Ig formed after immunization?
IgM
What antibody forms natural ABO blood antibodies?
IgM
What antibody is needed for t cell maturation?
IgD
What antibody is found in tiny amounts in plasma?
IgE
What antibody binds to mast cells and liberates histamine and other inflammatory responses?
IgE
Which Antibody attracts eosinophils?
IgE
Antibody is related to the allergic/ hypersensivity reaction connected with asthma?
IgE
Can you have a genectic predisposition to producing excess IgE?
Yes
What are antigen presenting cells?
These are cells that bind to and/or breakdown antigens. They present epitopes on their surfaces, or alter the antigen to make it more recognizable.
What are some examples of an antigen presenting cell?
B Cells, Macrophages, and dendritic cells all act as presenting cells.
What cells do antigen presenting cells present to?
T cells and sometimes phagocytizing cells
What are t cells responsible for?
cell mediated or cellular immunity
The secretion compounds of a t cell that communicate with immune system cells do what?
- attract cells
- prevent cells from leaving the area
- amplify effectiveness of cells
- increase or decrease cell reactions
- activate and regulate b cells
- signal natural killer cells
- increase local blood flow to facilitate immune cell movement
- determine if humoral or cellular immunity is needed
What cells help kill tumor cells?
T cells