Systemic Vasculitis Flashcards
Organ systems most commonly involved in paraneoplastic vasculitis (2)
Skin and nervous sytem
Classic triad of atrial myxoma
Embolism, intracardiac obstruction leading to pulmonary congestion, and constitutional symptoms
Neoplasm that may cause secondary polyarteritis nodosa
Hairy cell leukemia
Corticosteroid-sparing agent used in polymyalgia rheumatica
Methotrexate
Most common peripheral nerve manifestation of polyarteritis nodosa
Mononeuropathy or mononeuritis multiplex
Recommended treatment for Kawasaki disease
High-dose salicylates and IV immune globulin
Drug which has been shown to be as effective as cyclophosphamide in treating granulomatosis with polyangiitis
Rituximab
Maintenance treatment for granulomatosis with polyangiitis, Churg-Strauss syndrome, and microscopic polyangiitis
Azathioprine or methotrexate
Treatment for Churg-Strauss syndrome
High-dose corticosteroids
Indications for cyclophosphamide in Churg-Strauss syndrome
Neurologic, gastrointestinal, kidney, or cardiac involvement
Monoclonal immunoglobulins that self-aggregate and are associated with Waldenstrom macroglobulinemia and multiple myeloma; more commonly associated with hyperviscosity syndromes than vasculitis and nephritis
Type I cryoglobulins
Rheumatoid factors that are monoclonal IgM or IgA; most often associated with vasculitis and most commonly occurs in the setting of hepatitis C or HIV infections
Type II cryoglobulins
Type of cryoglobulins most often associated with autoimmune disorders such as SLE, Sjögren syndrome, and RA
Type III cryoglobulins
Primary presenting features of cryoglobulinemic vasculitis (3)
Cutaneous purpura, mononeuritis multiplex, and immune complex glomerulonephritis
Treatment for hepatitis C-associated cryoglobulinemia
Interferon alfa and ribavirin
