Systemic Lupus Erythematosus Flashcards
A chronic nonerosive deformity of the hands that is reducible; due to tendon inflammation rather than joint destruction; seen in SLE and rheumatic fever
Jaccoud arthropathy
Triggering of the innate immune system by viruses or endogenous ribonucleoprotein is thought to lead to production of this cytokine important in lupus pathogenesis
Type I interferons
Most commonly affected joints in SLE patients with osteonecrosis (2)
Hips and knees
Risk factors for osteonecrosis in SLE (2)
Corticosteroid use and presence of antiphospholipid antibodies
Kidney biopsy findings (3) in SLE indicating a poor prognosis
Class IV nephritis, cellular crescents, interstitial fibrosis
Clinical factors associated with progressive kidney failure in SLE:
age, ethnicity, hematocrit, creatinine level
Older age, black ethnicity, Hct <26%, creatinine 2.4 mg/dL (212.2 mmol/L)
Cardiac valve involvement in SLE is strongly associated with these autoantibodies
Antiphospholipid antibodies
Asymptomatic sterile vegetations that may lead to embolization or superimposed infective endocarditis
Libman-Sacks endocarditis
Disease-specific relative risk (RR) of atherosclerosis in SLE
7.5
Often the first hematologic symptom of SLE
Idiopathic thrombocytopenic purpura
Catastrophic antiphospholipid syndrome refers to acute thrombosis in at least this number of organs
3
Most sensitive test for anti-dsDNA antibodies
ELISA
In the differential diagnosis of SLE, this particular virus can cause joint pain with transiently positive autoimmune serologies
Parvovirus B19
Autoantibodies typically seen in classic drug-induced lupus (3)
ANA, anti-histone, anti-ssDNA
In contrast to the historically associated drugs, this class of drugs appear to induce lupus-like disease with positive anti-dsDNA and rare kidney/CNS involvement
TNF alpha inhibitors
