Approach/Therapeutics Flashcards

0
Q

Most vision threatening condition in rheumatoid arthritis

A

Scleral melt

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1
Q

Most common ocular condition in rheumatoid arthritis

A

Keratoconjunctivitis sicca (dry eyes)

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2
Q

Most of the anti-inflammatory and analgesic effects of NSAIDs is through reduction of this prostaglandin

A

Prostaglandin E2

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3
Q

The benefit of methotrexate in rheumatic diseases is related to this mechanism

A

Ability to raise extracellular adenosine levels

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4
Q

The only NSAID that appears to reduce cardiovascular risk

A

Naproxen

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5
Q

This drug combines the dual actions of engaging opiate receptors and raising serotonin and norepinephrine levels; more potent than acetaminophen; low potential for abuse

A

Tramadol

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6
Q

Dose and duration of corticosteroid therapy at which bisphosphonates are indicated to prevent osteoporosis

A

=>7.5 mg/d for more than 3 months

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7
Q

Most important toxicity of hydroxychloroquine

A

Visual loss from retinal pigment deposition

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8
Q

Mechanism of action of leflunomide

A

Blocks pyrimidine biosynthesis

targets lymphocytes, which lack pyrimidine salvage pathways

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9
Q

Drug given to remove leflunomide from the body in the event that the drug must be withdrawn

A

Cholestyramine (tid x 8 days)

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10
Q

Enzyme that metabolizes azathioprine

A

Thiopurine methyltransferase

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11
Q

Drugs that should be avoided in patients taking azathioprine

A

Allopurinol or febuxostat

active azathioprine metabolites are also degraded by xanthine oxidase

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12
Q

Mechanism of action of mycophenolate mofetil

A

Inhibits inosine monophosphate dehydrogenase (in the purine synthetic pathway)

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13
Q

Active metabolite of mycophenolate mofetil

A

Mycophenolic acid

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14
Q

Methotrexate should be discontinued for this duration prior to pregnancy

A

3 months

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15
Q

Monoclonal antibody that targets IL-12/IL-23 used in patients with psoriatic arthritis or IBD

A

Ustekinumab

16
Q

Biologic agent composed of a fusion protein of CTLA4 and Fc portion of IgG; binds to antigen-presenting cells and blocks costimulatory signals to T lymphocytes

A

Abatacept

17
Q

A chimeric (mouse-human) monoclonal antibody with specificity for the IL-6 receptor; used in patients with rheumatoid arthritis

A

Tocilizumab

18
Q

Blockade of this interleukin by ustekinumab attenuates the maturation and activation of Th1 lineage of T cells

A

IL-12

19
Q

Blockade of this interleukin by ustekinumab attenuates the maturation and survival of Th17 cells, a subset of T cells implicated in Crohn’s disease, psoriatic arthritis, and RA

A

IL-23

20
Q

Monoclonal antibody with specificity for B cell activating factor (BAFF), also referred to as B-lymphocyte stimulator (BLyS)

A

Belimumab

21
Q

IL-1 beta receptor antagonist that have proved beneficial in the treatment of adult-onset Still disease

A

Anakinra

22
Q

IL-1 beta inhibitors that have proved beneficial in the treatment of cryopyrin-associated periodic fever syndromes (2)

A

Rilonacept and canakinumab

23
Q

Renal tubule transporter inhibited by probenecid to block retention of urate

A

URAT1