Idiopathic Inflammatory Myopathies Flashcards
Idiopathic inflammatory myopathy caused by T-cell-mediated cytotoxicity
Polymyositis and inclusion-body myositis
Idiopathic inflammatory myopathy caused by dysregulation of the humoral immune system
Dermatomyositis
Classic symptom of both dermatomyositis and polymyositis
Symmetric proximal muscle weakness
Idiopathic inflammatory myopathy that more commonly affects men
IBM
Idiopathic inflammatory myopathy that is slowly progressive, with weakness in both proximal and distal muscle groups
IBM
A rare subset of dermatomyositis that presents as a typical rash in the absence of muscle symptoms
Amyopathic dermatomyositis
Most common pattern of interstitial lung disease in idiopathic inflammatory myopathies
Nonspecific interstitial pneumonitis
Antibodies associated with interstitial lung disease in inflammatory myopathies
Anti-Jo-1
Most common anti-synthetase antibody in inflammatory myopathies
Anti-Jo-1
Antibody associated with classic rash, cuticular overgrowth, milder muscle involvement, lower risk of ILD, and good prognosis in inflammatory myopathies
Anti-Mi-2
Target tissue of B cells and CD4-positive T cells in dermatomyositis
Vascular endothelium
Primary target of cytotoxic CD8-positive T lymphocytes in polymyositis and IBM
Myofibril
Biopsy finding in dermatomyositis which may be enough to establish the diagnosis without muscle biopsy in the appropriate clinical setting
Interface dermatitis
Initial therapy for dermatomyositis and polymyositis
High-dose corticosteroids
Cancer that is especially common in patients with inflammatory myopathies
Ovarian cancer
