Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Musculoskeletal and Connective Tissue > Systemic lupus erythematosus > Flashcards

Systemic lupus erythematosus Flashcards

1
Q

classic clinical presentation of SLE

A

rash, joint pain and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

SLE is MC in (sex, age, origin)

A

female of reproductive age and African descent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lupus endocarditis - name

A

Lidman - Sacks endocarditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Lidman - Sacks endocarditis of lupus?

A

nonbacterial, wart-lile (verrucous) vegetations on both sides of valve (mitral) or aortic valve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Lupus nephritis is a result of

A

type III hypersensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lupus nephritis - MC

A

nephritic - diffuse proliferative glomerulonephritis
nephrotic - membranous glomerulonephritis
MC and severe type is diffuse proliferative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Common causes of death in SLE

A
  1. cardiovascular disease
  2. Infection
  3. Renal disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

SLE symptoms/findings/treatment etc

A

mnemonic: RASH OR PAIN
Rash, Arthritis, Soft tissues/Serositis, Hematologic disorders, Oral and nasopharyngeal ulcers, Renal disease/Raynaud phenomenon, Photosensitivity, Antinuclear antibodies, Immunologic disorfer (anti-dsDNA, anti-SM, antiphospholipids), Neurologic disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SLE - neurologic disorders - examples

A

seizures, psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SLE - hematologic disorders - example

A

pancytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SLE - heart

A

it can affect any layer of the heart (endo,myi,pericarditis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

SLE - rash

A

malar or discoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SLE - treatment

A
  1. NSAID 2. Steroids 3. immunosuppressants

4. hydroxychloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SLE - lab findings

A
  1. antinuclear antibodies (ANA)
  2. anti-dsDNA antibodies
  3. anti-Smith antibodies
  4. decreased C3, C4, CH50
  5. Anti-histone antibodies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SLE -decreased C3, C4, CH50 due to

A

immune complex formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SLE- sensitive, not specific test

A

ANA

17
Q

SLE - specific, poor prognosis test

A

anti-dsDNA (renal disease)

18
Q

SLE - specific, not prognostic test

A

anti-Smith

19
Q

SLE - sensitive for drug induced lupus

A

antihistone antibodies

20
Q

Anti-Smith antibodies - against ….

A

snRNPs

21
Q

antiphospholipid syndrome is a …. or …. disorder

A

1ry or 2ry autoimmune disorder

22
Q

antiphospholipid syndrome as a 2ry autoimmune disorder is MC in

A

SLE

23
Q

antiphospholipid syndrome - autoantibodies against

A

phospholipids

24
Q

diagnosis of antiphospholipid syndrome is based on

A

clinical criteria and lab findings

25
Q

clinical criteria of antiphospholipid syndrome

A
  1. history of thrombosis (arterial or venous)

2. recurrent spontaneous abortion

26
Q

antiphospholipid syndrome arterial or venous thrombosis includes

A
  1. DVT
  2. hepatic vein thrombosis
  3. placental thrombosis
27
Q

antiphospholipid syndrome - lab findings

A
  1. lupus anticoagulants
  2. anticardiolipin
  3. anti-β2 glycoprotein antibodies
28
Q

Lupus anticoagulant is an

A

immunoglobulin that binds to phospholipids and proteins associated with the cell membrane.

29
Q

antiphospholipid syndrome - lupus anticoagulants and anticardiolipin antibodies can cause …. (lab)

A

false positive VDRL/RPR

falsely elevated PTT

30
Q

antiphospholipid syndrome - treatment

A

systemic anticoagulation

31
Q

Drug induced lupus - drugs

A
  1. Hydralazine
  2. Procainamide
  3. Isoniazid
32
Q

Lupus endocarditis - valves

A
  1. mitral

2. aortic

33
Q

Mixed connective tissue disease - clinical presentation

A

Feature of SLE, systemic sclerosis, and/or polyomyositis

34
Q

Mixed connective tissue disease - Labs

A

anti-U1 RNP antibodies (speckled ANA)

35
Q

SLE - lab findings (and their characteristics)

A
  1. antinuclear antibodies (ANA) - sensitive, Not specific
  2. anti-dsDNA antibodies - Specific, poor prognosis (renal disease)
  3. anti-Smith antibodies - Specific, not prognostic (directed against snRNPs)
  4. decreased C3, C4, CH50 - due to immune complex formation
  5. Anti-histone antibodies - sensitive for drug-induced lupus)

Musculoskeletal and Connective Tissue (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions