Systemic Diseases with Skin Flashcards

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1
Q

what are skin findings of AL amyloidosis?

A

macroglossia
pinch purpura
nodules and plaques in periorbital region

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2
Q

what disease has pinch purpura with macroglossia?

A

AL amyloidosis

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3
Q

what type of granulomas are in sarcoidosis?

A

non caseating

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4
Q

how does sarcoid appear on skin?

A

symmetric red/brown papules and plaques

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5
Q

what is lofgrens syndrome?

A

sarcoidosis with erythema nodosum, hilar lymphadenopathy fever and polyarthritis

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6
Q

what do sarcoidosis skin lesions have a preference for?

A

tattoos and scars

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7
Q

a patient with history of diabetes presenting with reddish brown plaques on her shins may have what issue?

A

necrobiosis lipoidica

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8
Q

what is necrobiosis lipoidica?

A

necrotizing skin condition affiliated with diabetes

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9
Q

what do lesions look like with necrobiosis lipoidica?

A

reddish brown plaques on shins

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10
Q

what happens to sensation around plaques from necrobiosis lipoidica?

A

loss of sensation over the plaques

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11
Q

what is first line treatment for necrbiosis lipoidica?

A

topical steroids

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12
Q

what is Sweets Syndrome other name?

A

acute febrile neutrophilic dermatosis

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13
Q

what happens in Sweets syndrome?

A

fever with abrupt onset of erythematous plaques

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14
Q

where do plaques commonly occur in sweets syndrome?

A

head neck and upper extremities

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15
Q

what will labs show with Sweets syndrome?

A

elevated WBC with high neutros

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16
Q

what is a common trigger for Sweets syndrome? what is another trigger to be aware of?

A

infections

be aware of malignancies and chronic inflamm disorder

17
Q

what is treatment for Sweets disorder?

A

treat underlying infection or disease and give systemic steroids

18
Q

how does erythema nodosum appear on skin?

A

tender nodules on anterior lower legs without ulcerations

19
Q

does eryhtema nodosum have ulcerations?

A

NO

20
Q

50% of erythema nodosum is idiopathic…but other 50% has a few common triggers..what are they?

A
post strep infection
OCPs
Abx
pregnancy 
chronic inflamm disorders
21
Q

how to treat erythema nodosum

A

NSAIDs

22
Q

what are systemic symptoms of erythema nodosum?

A

arthritis
fever
arthralgia
malaise

23
Q

what is skin manifestation that is associated with ESRD?

A

calcific uremic arteriopathy

24
Q

what does skin look like in calcific uremic arteriopathy?

A

violaceous subcutaneous nodules and plaques

25
Q

is calcific uremic arteriopathy painful on skin?

A

you betcha

26
Q

what can calcific uremic arteriopathy lead to on skin?

A

ulcers

27
Q

where do you find the nodule and plaques from calcific uremic arteriopathy?

A

lower extremities and trunk

28
Q

what does biopsy show in calcific uremic arteriopathy?

A

arteriolar calcification

29
Q

what do you do to help calcific uremic arteriopathy?

A

surgical debridement