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Syphilis Flashcards

1
Q

Syphilis is caused by

A

Treponema pallidum
STD

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2
Q

Treponema pallidum spirals

A

10-20

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3
Q

Clinical classification

A

Early syphilis
Late syphilis
Congenital syphilis

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4
Q

Early syphilis stages

A

Primary syphilis
Secondary syphilis
Latent syphilis

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5
Q

Inflammation at inoculation site and regional lymph node inflammation occurs at with stage of early syphilis

A

Primary syphilis

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6
Q

Bacteremia
Exanthem
Systemic signs
Antibodies are seen in which stage of early syphilis

A

Secondary syphilis

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7
Q

Symptom free with positive serological is seen in which stage of early syphilis

A

Latent syphilis

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8
Q

Granulomatous inflammation with cellular immune response is seen in

A

Late syphilis

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9
Q

Syphilis occurring more than 2 years after primary infection is

A

Late syphilis

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10
Q

Organs involved in late syphilis are

A

Skin
Bones
CVS
CNS

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11
Q

Congenital syphilis is also known as

A

Syphilis connata

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12
Q

Congenital syphilis is transmitted via

A

Placenta

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13
Q

Late syphilis is seropositive or seronegative

A

Seronegative

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14
Q

What happens at sight of entry in primary syphilis

A

Dark red nodule develops
Then becomes eroded and ulcerated

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15
Q

Chancre

A

Firm circumscribed ulcer

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16
Q

Chancre locations

A

Prepuce
Glans
Perianal region
Vagina cervix
Labia majora labia minora
Rectum
Lips
Tongue
Palette
Finger

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17
Q

Chancre is followed by __________ in primary syphilis

A

Regional lymphadenopathy

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18
Q

Diagnosis

A

Dark field microscopy
FTA (Fluorescent Treponemal antibody) technique

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19
Q

The rashes in secondary syphilis are called

A

Syphilids

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20
Q

Are rashes pruritic in secondary syphilis

A

No
And no scaling

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21
Q

Syphilis rash clinical features

A

Pink macules (red brown) on
Side of chest then to
Trunk
Palms
Soles

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22
Q

Is rash in secondary syphilis blanchable?

A

Yes

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23
Q

Are there mucosal changes in secondary syphilis

A

Yes

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24
Q

Mucosal changes in secondary syphilis

A

Plaques on oral mucosa that can be eroded
Tonsils
tongue

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25
Systemic changes in secondary syphilis
Generalized lymphadenopathy Acute hepatitis Acute Glomerulonephritis Splenomegaly Meningitis Meningoencephalitis
26
Syphilitic handshake
Antecubital lymphadenopathy palpation
27
Are there musculoskeletal abnormalities in secondary syphilis
Yes
28
Musculoskeletal abnormalities in secondary syphilis
Periostitis Polyarthritis Tenosynovitis
29
Diagnosis of secondary syphilis
Serology 100% positive
30
Prognosis in secondary syphilis
Good All lesions resolve
31
Latent syphilis
After secondary syphilis resolution. No clinical manifestation but serology is positive
32
Tertiary syphilis manifestations
Cutaneous Musculoskeletal Cardiovascular CNS
33
Tertiary syphilis Cutaneous manifestation
Tuberous syphilid Gumma
34
Grouped red brown papules that clear centrally and expand peripherally are called___________and seen in which syphilis?
Tuberoserpiginous syphilis and seen in tertiary syphilis
35
Gumma
Subcutaneous nodules Solitary
36
Are gumma painful?
No they are painless
37
Why does gumma discharge?
Because they often ulcerate leading to discharge
38
Gumma sites
Palate (perforation) Nose (saddle nose) Scalp Face Liver Bones Testes
39
Musculoskeletal disease in tertiary syphilis
Periostitis Osteolysis Gummata Juxtaraticular nodes
40
Juxtaarticular nodes
Gummata that do not liquefy
41
Osteolysis complication
Ivory bone: bone marrow sclerosis No bone marrow and blood vessels in bone marrow cavity
42
How does treponema pallidum affect the aorta
It affects vasa vasorum leading to Aneurysm and Aortic insufficiency
43
In late syphilis CNS symptoms are caused by
Chronic vessel inflammation
44
Quaternary syphilis includes
General paresis Tabes dorsalis
45
General paresis
Paralysis Damage to grey matter of anterior lobe Psychiatric diseases
46
Tabes dorsalis
Damage to Dorsal root and Posterior columns of spinal cord
47
Tabes dorsalis stages
Anesthetic stage Ataxic stage Pseudoparetic stage
48
Anesthetic stage
Hypesthesia Leads to neurotropic ulcer Lacinating abdominal pain Extremity pain
49
Paralysis of ocular nerve is seen in
Quaternary syphilis Tabes dorsalis Anesthetic stage
50
Hypesthesia
Loss of sensitivity
51
Ataxic stage
Romberg sign positive Uncoordinated movements with typical locomotion (slap walk)
52
Romberg sign
Unable to stand steady with eyes closed
53
Pseudoparetic stage
Signs and symptoms of paresis
54
Congenital syphilis subtypes
Early congenital syphilis (before 2 yrs) Late congenital syphilis (after 2 yrs)
55
Mother with early syphilis (less than 2 yrs)
Dangerous for fetus
56
Mother with late syphilis (greater than 2 yrs)
Child little risk
57
During pregnancy 1st half
Death of child
58
During pregnancy 2nd half
Child can develop late congenital syphilis and mother secondary syphilis
59
Early congenital syphilis signs
Low birth weight Hepatosplenomegaly Blisters and erosions on palms and soles Osteomyelitis
60
Early congenital syphilis Development in first month in untreated infants
Chronic runny nose, often bloody Periorificial rhagades Pemphigus syphiliticus Periostitis Osteochondritis CNS disease Glomerulonephritis
61
Late congenital syphilis
Similar to late syphilis CVS involvement is uncommon
62
Interstitial keratitis is seen in
Late congenital syphilis
63
Interstitial keratitis
Affect iris (iritis) Corneal neovascularization and clouding
64
Interstitial keratitis treatment
Topical corticosteroids No antibiotics as it can cause flare up Corneal transplantation
65
Sensory deafness and neurosyphilis are seen in which congenital syphilis
Late congenital syphilis
66
Gummata and tuberous lesions are seen in
Late congenital syphilis and Tertiary syphilis
67
Clinical lesions secondary to congenital syphilis
Saddle nose Frontal bossing Maxillary hypoplasia Higoumenaki sign Saber shins Clutton joints Gothic palate (high arched palate) Periorificial rhagades Dental changes: Hutchison incisors Mulberry molars
68
Hutchinson triad includes
Hutchison incisors Sensory deafness Interstitial keratitis
69
Higoumenaki sign
Thickening of medial end of clavicle
70
Clutton joints
Effusion into large joints
71
Syphilis treatment
Penicilin Doxycycline Erythromycin

Dermatology (31 decks)

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