Acne Vulgaris Flashcards
Acne vulgaris
Follicular plugging
Pathogenesis
Increased androgens in men
Increased androgenic properties of progesterone in women
Follicular keratinization: hyperkeratotic plugs in follicular opening
Hyperplasia of sebaceous glands
Propionibacterium acne in follicles
Propionibacterium acnes releases what
Lipase
It splits free fatty acids and releases inflammatory mediators
Acne vulgaris classification
Acne comedonica
Acne papulopustulosa
Acne comedonica
Open comedon - white heads
Closed comedon - blackheads
Comedones
Comedones develope in sebaceous follicles on face, chest and mid back
With small hair and large sebaceous glands
Black colour in comedones are from
Follicle melanin ,not dirt
Most common sites for comedones are
Forehead
Cheeks
Perioral region
Acne papulopustulosa
Comedone ruptures
Neutrophils are attracted
And pus
Therapy
Retinoids
Isotretinoin
Benzoyl peroxide
Tetracycline
Anti androgens
