Lupus Erthematosus Flashcards
LE
Autoimmune disorder involving multiple organs
LE classification
Chronic cutaneous LE (only skin findings)
Subacute cutaneous LE (skin and mild systemic involvement)
Systemic LE (primarily systemic involvement)
Chronic cutaneous LE includes
Discoid LE
Lupus tumidus
Lupus profundus
Pathogenesis
Genetic
Autoimmune
Nuclear antigen (apoptosis)
UV
Medication
Maternal autoantibodies can lead to neonatal LE
Diagnosis
Lupus band test
Chronic cutaneous LE
Scarring erythematosquamous lesions
Primarily in sun exposed skin
Chronic cutaneous LE clinical features
Eryhtematous persistent plaques
Follicular hyperkeratosis
Telangiectasis
Heal with scarring
Peripheral hyperpigmentation
Central hypopigmentation
Chronic cutaneous LE predilection sites
Scalp
Forehead
Cheeks
Ears
Nose
Upperlip and
Chin
Are lesions limited or disseminated?
Limited
Diagnosis
Skin biopsy
Immunofluorescence
Low ANA
IgG and C3 along basement membrane
Therapy
Tacrolimus
Corticosteroids
Dapsone
Subacute cutaneous Lupus Erythematosus
Symmetrical
Non scarring
Diagnosis
Skin biopsy
Anti SSA and Anti SSB positive
ANA negative
IgG and C3 along basement membrane in lesion
Neonatal Lupus erythematosus
Mother with
Anti SS A and anti SS B
Transfer them via placenta to the fetus
Affects fetal cardiac conduction system antigens
Clinical features of neonatal LE
SCLE annular
Complication of neonatal LE
Congenital heart block
Diagnosis
Anti SSA and SSB
Therapy
Corticosteroids
SLE cutaneous lesions
Butterfly rash
Diffuse Erythema of scalp, ears, lips, upper trunk, forearms
Exanthem
Bullous lesion
Discoid lesion
Alopecia
Palatal erosin and erythema
Damaged cuticle with telangiectasis
Vasculitis
SLE systemic lesions
ACR Criteria
4 organ damage:
Arthritis
Malar rash
Discoid rash
Oral ulcer
Photosensitivity
Serositis (pleuritis or pericarditis)
Renal disease
CNS disease
Hematological disorder
Immunological disorder
Anti nuclear antibody
Therapy
Antimalarial
NSAID
Corticosteroids
