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Dermatology > Lupus Erthematosus > Flashcards

Lupus Erthematosus Flashcards

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Dermatology Board Prep flashcards
1
Q

LE

A

Autoimmune disorder involving multiple organs

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2
Q

LE classification

A

Chronic cutaneous LE (only skin findings)
Subacute cutaneous LE (skin and mild systemic involvement)
Systemic LE (primarily systemic involvement)

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3
Q

Chronic cutaneous LE includes

A

Discoid LE
Lupus tumidus
Lupus profundus

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4
Q

Pathogenesis

A

Genetic
Autoimmune
Nuclear antigen (apoptosis)
UV
Medication
Maternal autoantibodies can lead to neonatal LE

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5
Q

Diagnosis

A

Lupus band test

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6
Q

Chronic cutaneous LE

A

Scarring erythematosquamous lesions
Primarily in sun exposed skin

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7
Q

Chronic cutaneous LE clinical features

A

Eryhtematous persistent plaques
Follicular hyperkeratosis
Telangiectasis
Heal with scarring
Peripheral hyperpigmentation
Central hypopigmentation

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8
Q

Chronic cutaneous LE predilection sites

A

Scalp
Forehead
Cheeks
Ears
Nose
Upperlip and
Chin

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9
Q

Are lesions limited or disseminated?

A

Limited

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10
Q

Diagnosis

A

Skin biopsy
Immunofluorescence
Low ANA
IgG and C3 along basement membrane

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11
Q

Therapy

A

Tacrolimus
Corticosteroids
Dapsone

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12
Q

Subacute cutaneous Lupus Erythematosus

A

Symmetrical
Non scarring

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13
Q

Diagnosis

A

Skin biopsy
Anti SSA and Anti SSB positive
ANA negative
IgG and C3 along basement membrane in lesion

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14
Q

Neonatal Lupus erythematosus

A

Mother with
Anti SS A and anti SS B
Transfer them via placenta to the fetus
Affects fetal cardiac conduction system antigens

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15
Q

Clinical features of neonatal LE

A

SCLE annular

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16
Q

Complication of neonatal LE

A

Congenital heart block

17
Q

Diagnosis

A

Anti SSA and SSB

18
Q

Therapy

A

Corticosteroids

19
Q

SLE cutaneous lesions

A

Butterfly rash
Diffuse Erythema of scalp, ears, lips, upper trunk, forearms
Exanthem
Bullous lesion
Discoid lesion
Alopecia
Palatal erosin and erythema
Damaged cuticle with telangiectasis
Vasculitis

20
Q

SLE systemic lesions

A

ACR Criteria
4 organ damage:
Arthritis
Malar rash
Discoid rash
Oral ulcer
Photosensitivity
Serositis (pleuritis or pericarditis)
Renal disease
CNS disease
Hematological disorder
Immunological disorder
Anti nuclear antibody

21
Q

Therapy

A

Antimalarial
NSAID
Corticosteroids

Dermatology (31 decks)

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