Synthetic Antibacterial Agents pt. 2

Question 1

First nitroheterocyclic chemotherapeutic compounds

Answer 1

Nitrofurans

Question 2

An aldehyde dehydrogenase inhibitor with bactericidal and antiprotozoal activity against G. lamblia

Answer 2

Furazolidone

Question 3

A nitrofuran that disrupts bacterial enzyme system and active against G(+) and G(-)

Answer 3

Nitrofurantoin

Question 4

Used against G(+) and G(-) bacteria and has 0.2% concentration in sol’n, ung and suppositories.

Answer 4

Nitrofurazone

Question 5

Phenazopyridine HCl + Sulfisoxazole = available as ___.

Answer 5

Sulfamethoxazole (Azo-grantrisin) - Treat UTI

Question 6

Readily absorbed after oral administration and highly concentrated in the urinary bladder.

Answer 6

Methenamine Hippurate

Question 7

Available as Urothropin® and Uritone®

Answer 7

Methenamine

Question 8

Use of methenamine

Answer 8

Urinary antiseptic

Question 9

Methenamine requires an acidifying agents like _______ _______ or ______ _________

Answer 9

ammonium chloride or sodium bisphosphate

Question 10

Treatment of isoniazid resistant TB

Answer 10

Ethionamide

Question 11

Bactericidal against replicating organisms, but bacteriostatic against nonreplicating organisms

Answer 11

Isonicotinic hydrazide

Question 12

Bioactivated to pyrazinoic acid.

Answer 12

Pyrazinamide

Question 13

Binds to bacterial DNA-dependent RNA polymerases

Answer 13

Rifampicin

Question 14

Rifampicin is the most active agent for clinical tx of TB.

T or F

Answer 14

True

Question 15

Has slow, bactericidal effects and used for dapsone-resistant leprosy, and skin lesions by M. ulcerans.

Answer 15

Clofazamine

Question 16

Lower plasma concentration than Rifampicin.

Answer 16

Rifabutin

Question 17

Interferes with incorporation of p-aminobenzoic acid into folic acid.

Answer 17

p-aminosalicylic acid

Question 18

Active only against dividing bacteria.

Answer 18

Ethambutol

Question 19

Second line agents for TB.

Answer 19

Cycloserine
Capreomycin
Streptomycin

Question 20

Streptomycin is administered ______ and inhibits protein synthesis by binding to the ___ ribosomal unit

Answer 20

intramuscularly, 12S ribosomal unit

Question 21

Inhibits protein synthesis by binding to the 70S ribosomal unit.

Answer 21

Capreomycin

Question 22

Sterically and stereochemically analogous to D-alanine

Answer 22

Cycloserine

Question 23

This is a sulfonamide drug closely related to sulfisoxazole in chemical structure and antimicrobial activity

Answer 23

Sulfamethoxazole