Anti-Viral Agents pt. 2

Question 1

Drugs act as Reverse Transcriptase Inhibitors (8)

Answer 1

Zidovudine, Didanosine, Zalcitabine,Stavudine, Abacavir, Tenofovir disoproxil, lamivudine, emtricitabine

Question 2

A prodrug analog with Abacavir and synergistic with RT inhibitors for HIV adult patients.

Answer 2

Tenofovir disoproxil

Question 3

Orally active nucleoside reverse-transcriptase inhibitor

Answer 3

Emtricitabine

Question 4

The triphosphate form of this drug is a nucleoside reverse transcriptase inhibitor in combination therapy for HIV and AIDS.

Answer 4

Abacavir

Question 5

This drug has antiretroviral activity against HIV and low toxicity.

Answer 5

Lamivudine

Question 6

Lamivudine together with Azidothymidine increases CD4 count.

T or F

Answer 6

True

Question 7

Close congener of AZT, thymidine nucleoside analog

Answer 7

Stavudine

Question 8

What is the dose-limiting effect of Stavudine

Answer 8

peripheral neuropathy

Question 9

MOA of Stavudine

Answer 9

Triphosphate form competitively inhibits incorporation of thymidine triphosphate into retroviral DNA

Question 10

Known as the former Azidothymidine and used against HIV 1 and 2

Answer 10

Zidovudine

Question 11

MOA of Zidovudine

Answer 11

Triphosphate form competitively inhibits reverse transcriptase, causes DNA chain termination – yielding incomplete proviral DNA

Question 12

RTI that is active against HIV 1, 2, and AZT resistant forms.

Answer 12

Zalcitabine

Question 13

Zalcitabine works by the inhibition of the enzyme __________ caused by ____________ which causes termination of viral DNA chain elongation.

Answer 13

Reverse transcriptase

Dideoxycytidine triphosphate (ddCTP)

Question 14

A purine nucleoside analog and is 10-100 fold less potent that Azidothymidine but less myelosupression.

Answer 14

Didanosine

Question 15

Didanosine is also used as a treatment for AIDS patients with intolerance to AZT.

T or F

Answer 15

True

Question 16

Didanosine and Zalcitabine inhibits the both enzymes.

T or F

Answer 16

True

Question 17

Drug acts as Miscellaneous Nucleoside Antimetabolites

Answer 17

Ribavirin

Question 18

Ribavirin is known to inhibit RNA and DNA viruses replication.

T or F

Answer 18

True

Question 19

Drugs known as Non-Nucleoside Reverse Transcriptase Inhibitors

Answer 19

Nevirapine
Delavirdine
Efavirenz

Question 20

1. Non-Nucleoside Reverse Transcriptase Inhibitors have specific activity against HSV-1.
2. The rapid emergence of resistance prohibits multitherapy with any of the NNRTIs and the NRTIs or the protease inhibitors.

a. First statement is correct.
b. Second statement is correct.
c. Both of the statements are correct.
d. Both of the statements are incorrect.

Answer 20

a. First statement is correct.
1. Non-Nucleoside Reverse Transcriptase Inhibitors have specific activity against HSV-1.
2. The rapid emergence of resistance prohibits MONOTHERAPY with any of the NNRTIs and the NRTIs or the protease inhibitors.

Question 21

Delavirdine binds directly to a site on the viral reverse transcriptase that is near to but distinct from the binding site of the NRTIs (Allosteric Site)

T or F

Answer 21

True

Question 22

Drugs that inhibit non-nucleoside reverse transcriptase compete with nucleoside triphosphate but require phosphorylation to be active.

T or F

Answer 22

False

These drugs neither compete with nucleoside triphosphate nor require phosphorylation to be active

Question 23

Arrests replication of the virus at the maturation step to prevent spread of cellular infection.

Answer 23

HIV Protease Inhibitory Drugs

Question 24

Drugs that inhibit HIV Protease

Answer 24

Tipranavir
Fosamprenavir
Atazanavir
Indinavir
Lopinavir
Nelfinavir
Amprenavir
Ritonavir
Saquinavir

Question 25

Used against HSV-1 and HSV-2 and against varicella-zoster virus, Epstein-Barr Virus and Cytomegalovirus

Answer 25

Acyclovir

Question 26

Approved for combination w/ Ritonavir

Answer 26

Lopinavir