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org med > Antiprotozoal Agents > Flashcards

Antiprotozoal Agents Flashcards

1
Q

Treatment of intestinal amebiasis

A

Iodoquinol

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2
Q

Long term A/E of Iodoquinol

A

optic neuritis and peripheral neuropathy

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3
Q

Agent of choice for C. difficile infections

A

Metronidazole

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4
Q

Used for tx of dysentery, giardiasis, trichomoniasis and active against all anaerobic cocci, G(-)

A

Metronidazole

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5
Q

T or F. Metronidazole is stable for IV preparation.

A

False

Metronidazole is UNSTABLE for IV preparation. Reconstituted needed

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6
Q

Treatment of asymptomatic carriers of E. histolytica, giardia cysts, and extraintestinal amebiasis

A

Diloxanide

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7
Q

Agent of choice for prophylactic infections of P. carinii

A

Pentamidine isethionate

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8
Q

True or False. Pentamidine isethionate can be use as an alternative for Suramin in African sleeping disease, Kala-Azar, Babesiosi.

A

True

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9
Q

Second line tx of Cotrimoxazole intolerant mild-moderate P. carinii infections. Also treats P. carinii, T. gondi

A

Atovaquone

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10
Q

An amebicidal Ipecac protoplasmic poison and used for the treatment of invasive, instestinal amebiasis, amebic abscess, amebic hepatitis, balantidial, fluke infestation

A

Emetine

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11
Q

This the only active agent agent against T. cruzi

A

Nifurtimox

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12
Q

Known as Ordinyl and used to treat African sleeping sickness, and meningoencephalic stage of T. brucei

A

Eflornithine

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13
Q

MOA of Eflornithine

A

Enzyme activated inhibitor of ornithine decarboxylase.

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14
Q

Treatment of Chagas disease

A

Benznidazole

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15
Q

Adverse effects of Benznidazole

A

Peripheral neuropathy, bone marrow suppression

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16
Q

For tx and prophylaxis of trypanosomiasis

A

Suramin sodium

17
Q

This drug is used for the treatment of meningoencephalic forms of T. gambiense, T. rhodesiense and an agent of choice for late stages of African trypanosomiasis.

A

Melarsoprol

18
Q

Agent of choice for Leishmaniasis

A

Sodium stibogluconate

19
Q

Potent taeniacide that causes rapid disintegration of worm segments and the scolex.

A

Niclosamide

20
Q

Treatment of pinworm and roundworm and depolarizes NMB that causes spastic paralysis

A

Pyrantel Pamoate

21
Q

Treatment of pinworm and roundworm

A

Piperazine

22
Q

MOA of Piperazine

A

Blocks response of ascaris muscle to acetylcholine causing flaccid paralysis

23
Q

Thiabendazole inhibits the helminth-specific enzyme ________, also arrest nematode cell division in _______ by interfering with microtubule assembly.

A

Inhibits the helminth-specific enzyme FUMARATE REDUCTASE, also arrest nematode cell division in METAPHASE by interfering with microtubule assembly

org med (13 decks)

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