Anxiolytic Agents

Question 1

MOA of Benzodiazepines

Answer 1

Enhance GABAergic transmission and increase frequency of GABAergic channel openings

Question 2

Drugs under 3-hydroxybenzodiazepines (GN and BN)

Answer 2

Lorazepam (Ativan)

Oxazepam (Serax)

Question 3

What is the difference between the structure of Lorazepam and Oxazepam?

Answer 3

Lorazepam has 2-chlorinated phenyl ring.

Question 4

Drugs under Triazolo benzodiazepines (GN and BN)

Answer 4

Alprazolam (Xanax)

Triazolam (Halcion)

Question 5

What is the difference between the structure of Alprazolam and Triazolam?

Answer 5

Alprazolam has a phenyl group at position 6, with a chlorine atom at position 8 and with a methyl group at position 1.

Triazolam has no chlorine atom in the ‘ortho’ position of the phenyl ring.

Midazolam

Question 6

A short-acting imidazolo benzodiazepine

Answer 6

Midazolam (Versed)

Question 7

They enhance GABAergic transmission and increase opening time of GABAergic channel

Answer 7

Barbiturates

Question 8

This drug have a long (>6 hrs) half life and used as an anticonvulsant.

Answer 8

Phenobarbital

Question 9

These drugs have an intermediate (3-6 hrs) half life and used as pre op sedative.

Answer 9

Amobarbital and Butabarbital

Question 10

These drugs have an short (<3 hrs) half life and used for pre op sedation.

Answer 10

Pentobarbital and Secobarbital

Question 11

This drug have a long (>6 hrs) half life and used as a daytime sedative.

Answer 11

Mephobarbital

Question 12

These drugs have ultrashort (15-40 mins) half life and used for anesthesia induction.

Answer 12

Thiopental
Thiamylal
Methohexital