Synaptic Transmission & Neural Integration Flashcards

1
Q

What is a synapse?

A

functional association of a neuron with something else

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2
Q

What are the two types of synapses?

A

electrical & chemical

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3
Q

What do electrical synapses not have that chemical synapses do?

A

neurotransmitters

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4
Q

What links two neurons together?

A

gap junction

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5
Q

Synaptic Communication

A
  1. action potential
  2. voltage gated Ca2+ channels open, Ca2+ entry
  3. exocytosis
  4. neurotransmitter diffuses across cleft & binds to receptor
  5. response in cell
  6. neurotransmitter is removed
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6
Q

Are ligand-gated receptors considered fast or slow?

A

fast

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7
Q

Are GPCR receptors considered fast or slow?

A

slow

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8
Q

What is the most common CNS neurotransmitter for EPSP?

A

glutamate

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9
Q

What is the most common CNS neurotransmitter for IPSP?

A

GABA

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10
Q

What is EPSP responsible for?

A

depolarization

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11
Q

What is IPSP responsible for?

A

hyperpolarization

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12
Q

Which postsynaptic potential (PSP) is more likely to produce an action potential?

A

EPSP

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13
Q

What are the two graded potentials?

A

EPSP & IPSP

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14
Q

What are the two types of summation?

A

temporal & spatial

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15
Q

Temporal summation

A

sum of one synapse through time; EPSP is generated rapidly

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16
Q

Spatial summation

A

sum of several synapses at the same time; EPSP is generated simultaneously in different synapses

17
Q

What is the most abundant neurotransmitter in PNS?

A

acetylcholine

18
Q

Where is acetylcholine synthesized?

A

in axon terminal

19
Q

What is a disease associated with acetylcholine?

A

myasthenia gravis

20
Q

What are the two alpha adrenergic receptors?

A

alpha 1 & 2

21
Q

What are the 3 beta adrenergic receptors?

A

beta 1, 2, & 3

22
Q

Which beta adrenergic receptor has the greatest affinity for epinephrine?

A

beta 2

23
Q

What are the functions of serotonin?

A

regulating sleep & emotions

24
Q

What disease is associated with serotonin?

A

mental disorders

25
Q

What is the main location of serotonin?

A

brainstem

26
Q

What is the main location of histamine?

A

hypothalamus

27
Q

What amino acids are at excitatory synapses?

A

aspartate & glutamate

28
Q

What amino acids are at inhibitory synapses?

A

glycine & GABA