Synaptic Transmission Flashcards
Golgi staining of neurons is based on the precipitation of ____ ions and reveals detailed morphology of ____ ___.
Silver
Single cells
Reticular theory vs neuron doctrine: what does each state and which one is correct?
Reticular theory: neurons are a network that is one continuous connection (incorrect)
Neuron theory: neurons are separate cells with space between them; one cell must release and the other must detect (correct)
Synaptic cleft
Gap between pre- and post-synaptic neuron
Action potential causes release of _____ from the ___- synaptic terminal.
Neurotransmitters
Pre
Binding of neurotransmitter causes what to open on the post-synaptic neuron?
Ion channels
Ions flowing through channels causes change in the resting membrane potential of what on the post-synaptic cell?
Dendrites
Changes in membrane potential from dendrites is “integrated” where?
Axon hillock
The axon ___ ___ is enriched in voltage-gated K+ and Na+ channels.
Initial segment
If the membrane potential is above threshold, voltage-gated channels in the axon will do what?
Fire an action potential
The action potential travels what way down the axon?
Distally
Which is more common, a chemical or electrical synapse?
Chemical
In an electrical synapse, ____ flow from one cell to another through what?
Ions
Gap junction
A gap junction creates a ____ channel.
Continuous
Are the channels in electrical synapses ever closed?
No- they are always open
Is the distance between cells in an electrical synapse large or small?
Small
Is the pore size in an electrical synapse large or small? What 3 things can pass through the pores of an electrical synapse?
Large
Ions, ATP, neurotransmitters
What is the directionality of an electrical synapse?
Bidirectional
Is the speed of an electrical synapse fast or slow? How much time between pre- and post-synaptic neurons firing?
Fast
Less than 1 ms
Can many or few things modulate an electrical synapse?
Few
In a chemical synapse, a pre-synaptic neuron releases a _____ that binds to a post-synaptic neuron’s ____, causing an ____ ____.
Chemical
Receptors
Action potential
Is the distance between cells in a chemical synapse larger or smaller than that of an electrical synapse? Relatively speaking, is it large or small?
Larger
Small
Is the pore size of a chemical synapse larger or smaller than that of an electrical synapse? What can pass through it?
Smaller
Only ions
What is the directionality of a chemical synapse?
Unidirectional
Is the speed of a chemical synapse fast or slow? In comparison to an electrical synapse? How much time between pre- and post-synaptic neurons firing?
Fast
Slow
2-3 ms