Neuroanatomy Flashcards
Anterior
In front of
Posterior
Behind
Rostral
Top
Caudal
Bottom
Rostral and caudal when referring to the whole body designate what? When referring to the brain, designate what?
Whole body: rostral- closer to head, caudal- closer to toes
Brain: rostral- closer to front of brain, caudal- closer to back of brain
Dorsal
Back
Ventral
Front
Dorsal and ventral when referring to the whole body designate what? When referring to the brain, designate what?
Whole body: dorsal-closer to back, ventral- closer to front
Brain: dorsal- closer to top of brain, ventral- closer to bottom of brain
Superior
Above
Inferior
Below
Coronal
Plane that divides the body or brain into front and back halves
Sagittal
Plane that divides the body or brain into left and right halves
Horizontal/transverse
Plane that divides the body or brain into top and bottom halves
Medial
Closer to the spinal cord (body)/middle
Lateral
Further away from the spinal cord/middle
What does the CNS develop from?
Neural tube
What does the PNS develop from?
Neural crest (not just PNS) Cranial placodes
What parts of the PNS develop from the neural crest?
Dorsal root ganglia
Meninges
What part of the PNS develops from the cranial placodes?
Cranial nerves
What other structures develop from the neural crest?
Autonomic ganglia (guts)
Melanocytes
Smooth muscle
5 phases of early development after formation of zygote
Morula -> blastula -> gastrulation -> neurulation -> regionalization
2 layers of blastula
Top: epiblast
Bottom: hypoblast
What does the epiblast of the blastula develop into?
Embryo
What does the hypoblast of the blastula develop into?
Placenta
When does gastrulation begin?
When cells begin to migrate inward, forming primitive streak
Cells in the outer surface of the gastrula where the primitive streak was are called what?
Ectoderm
Cells in the inner layer of the gastrula that were pushed inward are called what?
Endoderm
Cells in between the ectoderm and endoderm are called what?
Mesoderm
Mesoderm is formed when?
Third wave of migration when additional cells migrate inward
Ectoderm forms what?
CNS and PNS
Endoderm forms what?
Microglia
Formation of primitive streak creates what 2 axes?
Rostral/caudal
Medial/lateral
The primitive node is at what end of the primitive streak?
Rostral
What is the first visible stage in nervous system formation?
Neurulation
During neurulation, what fuses and changes shape?
Ectoderm
What structure is formed during neurulation?
Neural tube
Where does the neural tube begin to close?
Near future brain stem
What 3 events occur during regionalization?
Neural tube is divided into different regions
Neurons are born
Cells stay in a certain region and develop differently from cells in a different region
Regional differences in cells are dependent on differences in what?
Gene expression Rates of cell division Cell shape Cell-cell adhesion Cell motility
4 divisions of the mammalian brain (see diagrams on slides 19 and 21)
Top to bottom: Forebrain Midbrain Hindbrain Spinal cord
Forebrain contains what 2 structures? (see diagrams on slides 19 and 21)
Telencephalon (front most part)
Diencephalon (underneath telencephalon)
Telencephalon contains what 2 parts?
Cortex (cerebrum)
Basal ganglia
Diencephalon contains what 2 parts?
Thalamus
Hypothalamus
Hindbrain contains what 3 parts? (see diagrams on slides 19 and 21)
Pons (top)
Medulla (bottom)
Cerebellum (side)
What 2 parts make up the brain stem?
Midbrain and hindbrain
Where specifically is the midbrain located?
Underneath the diencephalon and above the hindbrain
5 subdivisions of spinal cord nerves (top to bottom)
Cervical nerves Thoracic nerves Lumbar nerves Sacral nerves Coccygeal nerve
Cervical nerves control what?
Shoulders and arms
Thoracic nerves control what?
Mid-body
Lumbar nerves control what?
Legs and hips
What are the 4 lobes of the cerebrum? (see diagram on slide 23)
Clockwise top left to bottom: Frontal lobe Parietal lobe Occipital lobe Temporal lobe
What is the name of the groove that separates the frontal lobe from the parietal lobe?
Central sulcus
What is the name of the groove that separates the parietal lobe from the occipital lobe?
Parieto-occipital sulcus
What is the name of the groove that separates the temporal lobe from the frontal lobe?
Lateral fissure
Where is the primary motor cortex located relative to the central sulcus? The primary sensory cortex?
Primary motor cortex: rostral (in frontal lobe)
Primary sensory cortex: caudal (in parietal lobe)
Excitatory vs inhibitory
Excitatory: activates neuron it synapses on
Inhibitory: reduces activity of neuron it synapses on
Efferent vs afferent
Efferent: exiting
Afferent: arriving
Pyramidal neurons: what part of brain, projection or interneurons?
Cortex
Projection neurons
Pyramidal neurons have cell bodies in ____ but axons that project into ___ ___.
Cortex
Other regions
Pyramidial neurons are excitatory or inhibitory?
Excitatory
2 parts of basal ganglia (see diagram on slide 29)
Globus pallidus (innermost) Straitum (outermost)
The basal ganglia is ___ to the cortex.
Medial
The term nucleus in reference to the brain means what?
Group of neurons that have a specialized function
2 parts of striatum
Dorsal striatum
Ventral striatum
What does the dorsal striatum control?
Movement
2 parts of dorsal striatum (see diagram on slide 30)
Top to bottom:
Caudate
Putamen
What does the ventral striatum control?
Reward and emotion
2 parts of ventral striatum (see diagram on slide 30)
Amygdala (beneath putamen, under fold)
Olfactory tubercle
2 parts of globus pallidus (see diagram on slide 30)
External (in between putamen and internal)
Internal (next to external, medial to external)
The thalamus serves as what?
Relay station for sensory information
Thalamus is located _____ to the basal ganglia
Medially
Part of the thalamus responsible for vision information
Lateral geniculate nucleus
Part of the thalamus responsible for information from the face
Ventral posterior medial
Part of the thalamus responsible for information from the body and about pain/touch
Ventral posterior lateral
How spinal cord sections are labeled (2 axes)
Dorsal/ventral
Left/right (backwards to normal)
Gray matter refers to ___ ____ and white matter refers to ___.
Cell bodies
Axons
In a stain of a spinal cord, do the cell bodies actually appear gray and do the axons actually appear white?
No- their appearance is often the opposite
The gray matter of the spinal cord is divided into dorsal and ventral ____.
Horns
Function of dorsal horns
Receive sensory information
Function of ventral horns
Location of motor axons and cell bodies
The cervical and lumbar sections of the spinal cord have ___ dorsal and ventral horns than the thoracic section of the spinal cord.
Larger
Motor neurons are ___ from the spinal cord
Efferent
Each vertebra has a pair of ___ ____ ____. Where are the two located?
Dorsal root ganglia
One on the left, one on the right
Each dorsal root ganglia services a specific region of the ___, called a ____.
Skin
Dermatome
Cranial nerves service what 3 regions of the brain?
Midbrain
Pons
Medulla
Autonomic/enteric nervous system is divided into what 2 parts?
Parasympathetic
Sympathetic
Sympathetic nervous system controls what?
Fight or flight
Parasympathetic nervous system controls what?
Rest and digest
Ventricles are filled with what?
Cerebral spinal fluid
Cerebral spinal fluid is made in and pumped into the ventricles from what structure?
Choroid plexus
Cerebral spinal fluid flows from the ____ ventricle to the ____ ventricle to the ___ ventricle to the ____ ____ of the ___ ___.
Lateral
3rd
4th
Central canal of the spinal cord
Where are the lateral ventricles located relative to the 3rd and 4th ventricles?
Lateral ventricles are lateral to 3rd and 4th ventricles (medial to lateral ventricles)
Blood-brain barrier is made from fused ____ that surround ___ ____.
Astrocytes
Blood vessels
The astrocytes of the blood-brain barrier limit what into the brain?
Diffusion
3 layers of meninges (see diagram on slide 44)
Top to bottom:
Dura
Arachnoid
Pia
Function of the meninges
Protect brain