Synapse stabilisation Flashcards
What happens during the period of synapse elimination
Some fibres retract and remaining ones expand to their place through a process of non-random competition between synapses
What is discoordinated firing
Any MN firing leads to fibre contraction
What does blocking TTX lead to
A reduction in synapse loss
What is TTX
Tetrodoxin sodium channel blocker
What does deliberate non-coordinated firing do
Increases the rate of synapse loss
What is the processing of proBDNF to BDNF controlled by
Matrix Metalloproteinases (MMP)
What happens if there is low activity
Less MMP around and less BDNF so more proBDNF
What does the punishement reward system do
Rewards coordinated activty and punishes discoordination
What happens if you block eye opening during development
Most cells only respong to the light from one eye
What does the ocular dominace column suggest
Inputs compete for synaptic partners based on activity
What is BDNF secreted in response to
high frequency stimulation in the LTP
What doeS blocking of the TrkB do
Impairs ocular dominace column formation
What determines mature phenotypes
Transcription factors
What happens if you knock out Pea3
The motor neuron that innervates this muscle is not located laterally but centrally and you get a monosynpatic circuit forming
What does muscle-expressed neurotroph 3 induce
The expression of the proprioceptive sensory afferent
