Neuronal migration in CNS development Flashcards
What are the two classes of migration
Tangential and radial
What are early neuroepithelium cells classified as
Pseuodostratified due to the migration of the mitotically dividing nuclei
What are the neuroepthielial cells called when they start to divide assymetrically
Radial glia cells
What did Jospeh Altman and Shirley Bayer do to experiment in the 60s
They injected radioactive thymidine into the DNA of cells to follow neurogenesis and migration
What did Joseph Altman and Shirley Bayer find in their experiment
That cells in their final stage of division would retain the thymadine at high densities over time
What did they conclude from this experiment
Cells early on end up in the layers closest to the ventricular zone
Neurones born at different times have different fates
What do heterochronic transplants test
Whether the fates at different times are fixed or plastic
What does lissencephaly mean
Smooth brain caused by migration throughout the cortex due to lack of Reelin
What are microtubules ciritical for
Migration
What happens to radial glia cells over time
They become depleted
What are the granulate neurones in the dendrate gyrus of the hippocampus used for
Spatial awareness
What are the 3 classes of interneurons
GABAergic inhbitory interneurons which go out into the cortex
Dopaminergic go to the olfactory bulb
Cholinergic go to the striatum
Are there more neurons in the cerebellum or the cortex
Cerebellum
What do the earliest migrations form and what does this involve
They form a pre-plate which is made of two sets of cells known as the sub-plate neurons and the Cajal retzius cells
What is the pre-plate needed for
Delineating where the layers will form
