Synapse selection and induction Flashcards
What are the two key areas of synapses
The active zone which is full of synaptic vesicles
The post synaptic density
How does the structure of the axon come about
-The growth cone of the filopodia retracting and tight junctions form
-Membrane and extracellular glycoproteins form
-Presynaptic vesicles, dense extracellular matrix, post synaptic density and receptors accumulating in the celft
What can you see in immature synapses compared to mature
Fewer vesicles, the cleft is narrower and less extracellular matrix
What initiates synapti contact
Growth cone, parts of the pre and post synaptic cell, random physical interactions
When does synaptogenisis happen
When axons reach their targets, varies between regions
What happens after birth with regards to synaptogenesis
Synaptogenesis continues through into adolesence and adult
What can pre-synaptic specialisation be induced by
Nearby guidepost cells, some which will inhibit local synapse formation
What are the two classes of neuron called
RIA axons and interneurons
What do sheath cells secrete
Netrins and that guides the RIA axons ventrally down to the synpase site
What happens if you lose netrin
The targeting doesn’t happen and the synapses end up spreading out
What is neuroligin-neuroexin signalling associated with
ASD and schizophrenia
What do neuroligins and neuroexins allow
Spatial segregation of different inputs and outputs
What can different parts of the dendrite induce
Different forms of the synapses
Why do we study the neuromuscular junction
Its massive, simple and asscessible
Where is RNA initially expressed
At a low level of the myotubule nuclei, they are spread out over a low density
