Neural crest formation and dorsalisation posterior neural tube Flashcards
Why do we focus our experiments on the spinal cord
Simple structure, long, few surrounding tissues
What do neural plate border cells do
Seperates the neural plate from the epidermis
Generates the peripheral nervous system
What do neural plate border cells give rise to
Neural crest cells which form the peripheral nervous system
What are neural plate border cells crucial for
Neural crest formation/ peripheral nervous development
Roof plate formation and dorsal neural tube patterning
Final step of neuralation/ closure of the neural tube
What is the 1st step of neural crest formation
Early border is established. Begins to express certain tracription factors such as MXS
Second step of neural crest formation
Combination of extrinsic and extrinsic events, a neural plate border transcriptional signature develops
3rd step of neural crest cell formation
Other transcription factors are upregulated such as c-Myd, idm and snail
What does c-MYD do
Governs cell proliferation, main oncogene
What does id do
It has stem cell like behaviours
What does snail do
Sits at the top of events, makes cells undero epithelial to mesenchymal cell transition
Step 4 of neural crest formation
neural crest cell transcription factors upregulate a further set of genes
Promote epithelial-mesenchymal cell transition
Neural tube closes
Why are neural crest cells called 4th germ layer
They give rise to huge numbers of different cells such as schwann cells, melanocytes, osteoblasts and the gut
What are the different cell types generated determined by
The position of origin of the neural crest cells
Time generation of neural crest cells
Migratory pathway and signals they encounter en-route or at target
What are roof plate cells important for
The final step of neuralation and dorsal pattern of neural tube
What do neural plate cells express
BMPs
