Growth cones response to guidance: tactics of guidance Flashcards
What are the 3 growth cone domains
Central, transitional and peripheral
What are the lamella and filopodia made from
Different kinds of f-actin
Whats the lamella derived from
Basket work weaving of cross linked f-actin where they are at right angles
What are the filopodia derived from
They form larger bundles of f-actin and are highly polarised
What happens to tubulin in the resting growth cone
Its dragged sporadically into the filopodia (happens more dramatically when it comes into contact with attractive cues)
How do growth cones move
They don’t turn but they reorganise their cytoskeleton to start their growth in a new direction
What happens when f-actin accumulates
Stabalises the filopodium and drags microtubules into the back filopodium
What does growth-cone collapse do
Destabilises f-acin
What’s semaphorin
A family of inhbitory guidance cues, they can be membrane bound or secreted
What are the 4 tactics for axon guidance
Contact attraction, chemoattraction, contact repulsion and chemorepulsion
What do growth cones require
Substrates which are permissive for growth as attachment is not enoguh
What can permissive factors define
Substrate paths in embryo
What is laminin
A potent growth promoter, promotes the growth of neural cells
What happens if you block laminin
Slows down the growth of retinal axosn but does not change their direction
What are permissibe substrates called
Contact attractants
