Neuralation from neural plate to neural tube Flashcards
What will the transcriptional signature of any cell at a point in time tell us
What the cell is and at what stage its at
Whats a transcription factor that characterises early neural stem like cells
SOX2
What does overexpression of a neural inducer lead to
Induction of a secondary axis
What is neurulation
The elongation of the neural plate along the a p axis, rolling up into a neural tube
What drives neurulation
Gastrulation
What is gastrulation
The process which transforms the embryo from 1D into a multilayered embryo
What happens to the organisers in gastrulation
Change into this rod of axial mesodermal cells
What are the axial mesoderm cells composed of
Preochordal mesoderm and notochord
What does invagination involve
A sheet of cells bend inwards
What does ingression involve
Individual cells leave an epithelial sheet and become freely migrating mesenchyme cells
What does involution involve
An epithelial sheet rolls inward to form an underlying layer
What is Epiboly
A sheet of cells spreads by thinning
What is intercalation
Rows of cells move between one another, creating an array of cells that is longer
Convergent extension
Rows of cells intercalate but the intercalation is highly directional
What is a flat neural plate
Single layer epithelia
