Lecture 7 Flashcards
What does neurogenesis mean
The birth of a neurone
How do progenitor cells differentiate
They give rise to 3 cell types of the nervous system: Neurons, glia and astrocytes
Whats the ventricular zone
Progenitors that don’t differentiate and sit next to the lumen
What is interkinetic migration
When the cell is proliferating and the nuclei moves back and forth
Where does division occur
At the lumen
What happens once a cell has become a radial glia cell
It can divide symmetrically or assymmetrically
What happens when the radial glia cell divides assymetrically
It produces one identical daughter and one that becomes a neurone
What is one of the determing factors
Cell division plane
What is the best example for lateral inhibition
Notch
Whats lateral inhbition
The process by which a cell inhbits its neighbours to presume the primary fate
What do acheate-scute proteins do
They are transcription factors which directly regulate the expression of the delta genes and delta proteins
What is inhibited in neurogenesis
Notch signalling
How was notch pathway signalling discovered
Through drosophila
What is holoprosencephaly
A failure of the ventral forebrain to form due to mutations in shh signalling components
