Sympathomimetic Drugs

Question 1

Epinephrine

Answer 1

MOA:
β1-↑HR, ↑Inotropy, ↑SVR, ↑CO
β2- skeletal muscle vasodilation, bronchodilation (80% b)
α1- vasoconstriction (20% α)
Metabolism: Monoamine Oxidase / Catechol-O-MethylTransferase

Indications:
Life-threatening allergic rxn
Cardiopulmonary resuscitation
Cont. Infusion for increasing myocardial contraction

Question 2

Dopamine

Answer 2

MOA:
Endogenous catecholamine, acts on both dopaminergic & adrenergic receptors; used for hypotension, acute heart failure
Metabolism: Monoamine Oxidase / Catechol-O-MethylTransferase

Indications:
increase CO in pts. with low systemic BP, increased atrial filling pressure, and low urine output