Opioid Agonists

Question 1

MOA: ALL

Answer 1

Opioid Receptor Agonist

Question 2

Dose: Morphine

Answer 2

0.1-1 mg/kg IV

Question 3

VD: Morphine

Answer 3

3-5

Question 4

Half Life: Morphine

Answer 4

2-3 hours

Question 5

Dose: Meperidine (Demerol)

Answer 5

2.5-5 mg/kg IV

Question 6

VD: Meperidine (Demerol)

Answer 6

3-5

Question 7

Half Life: Meperidine (Demerol)

Answer 7

3-5 hours

Question 8

Dose: Fentanyl

Answer 8

Induction: 1-2 mcg/kg
gtt: 1-3 mcg/kg/hr

Question 9

VD: Fentanyl

Answer 9

2-8

Question 10

Half Life: Fantanyl

Answer 10

1-5 hours

Question 11

Context Sensitive Half Time: Fentanyl

Answer 11

4 hours

Question 12

Dose: Sufentanil

Answer 12

Induction: 1-2 mcg/kg; then 10-50 mcg PRN
Anesthesia: 8-30 mcg then 25-30 mcg

Question 13

VD: Sufentanil

Answer 13

2.5-3

Question 14

Half Life: Sufentanil

Answer 14

3 hours

Question 15

Context Sensitive Half Time: Sufentanil

Answer 15

30 minutes

Question 16

Dose: Alfentanil

Answer 16

Loading Dose: 8-100 mcg/kg

Maintenance: 0.5-3 mcg/kg/min

Question 17

VD: Alfentanil

Answer 17

0.4-1

Question 18

Half Life: Alfentanil

Answer 18

1-2 hours

Question 19

Context Sensitive Half Time: Alfentanil

Answer 19

60 minutes

Question 20

Dose: Remifentanil

Answer 20

Loading: 1 mcg/kg

Intra-Op: 0.5-3 mcg/kg/min

Question 21

VD: Remifentanil

Answer 21

0.3-0.4

Question 22

Half Life: Remifentanil

Answer 22

<10 min

Question 23

Context Sensitive Half Time: Remifentanil

Answer 23

4 minutes

Question 24

Naloxone (Narcan)

Answer 24

MOA: Competitive antagonism of opiate receptors
Dose: 0.4 mg (10 mcg/kg) may repeat q2-3 min
Half Life: 60-90 minutes