Non-Opioid Analgesics Flashcards
MOA: APAP
- Unclear.
- Para-aminophenol derivative
- Mechanism of action is not well understood (some recent evidence of COX-1, and speculation of COX-3)
- Equipotent to ASA in inhibiting central prostaglandin synthesis; with no effect peripherally
Dose: APAP
650-1000 mg IV q4-6 hours
Half Life: APAP
1-3 hours
Anesthesia Concerns: APAP
- Monitor BP.
- Do not exceed max daily dose (<2g/day) d/t hepatic enzyme induction and impaired glucuronidation.
Side Effects: APAP
N/V, HA, Insomnia, Hepatotoxic
MOA: Ibuprofen
COX-1 & COX-2 Inhibitor
Antipyretic
Anti-inflammatory
Analgesic
Dose: Ibuprofen
400-800 mg IV q 6 hours
Half Life: Ibuprofen
2.2-2.4 hours
Anesthesia Concerns: Ibuprofen
- Increased concern w/ pts at risk for renal dysfunction, altered platelet fxn, and GI irritation.
- Monitor BP.
- May increase fluid accumulation/edema in CHF pts.
Side Effects: Ibuprofen
Dizziness, epigastric pain, rash, tinnitus, renal dysfunction
MOA: Ketorolac (Toradol)
- Non- selective COX enzyme inhibitor
- Efficacy similar to morphine
Dose: Ketorolac (Toradol)
- 30 mg IV (50% reduction in patients > 65 or weight less than 50 kg) then 30 mg every 6 hours NOT to exceed 120 mg in 24 hrs
- Do not administer for longer than 5 days
Half Life: Ketorolac (Toradol)
2-6 hours
Anesthesia Concerns: Ketorolac (Toradol)
PDA closure when given peripartum, renal toxicity in pts with renal diseases, bleeding risk.
Side Effects: Ketorolac (Toradol)
Dyspepsia, HA, GI pain, nausea, somnolence, renal dysfxn
