Barbiturates Flashcards
1
Q
Induction Dose: Thiopental
A
4 (3-6) mg/kg IV
1
Q
MOA: Thiopental
A
GABA-mimetic
Anti-epileptic
2
Q
MOA: Thiopental
A
-Mimic the action of GABA by directly activating GABA(A) receptors
-Decreased rate of dissociation of GABA from receptors causing increased duration of receptor action.
-Depress reticular activating system.
Anti-epileptic
3
Q
VD: Thiopental
A
1.7-2.5
4
Q
Half Life: Thiopental
A
3-8 hours
5
Q
MOA: Methohexital
A
- Mimic the action of GABA by directly activating GABA(A) receptors
- Decreased rate of dissociation of GABA from receptors causing increased duration of receptor action.
- Depress reticular activating system.
- Faster than thiopental
6
Q
VD: Methohexital
A
1.9-2.2
7
Q
Half Life: Methohexital
A
1.5-5 hours
