Obstetric Medications Flashcards
MOA: Oxytocin (Pitocin)
Increases intracellular Ca+ levels within uterine smooth muscle cells to induce or strengthen uterine contraction
Indications: Oxytocin (Pitocin)
- Induction of Labor in the setting of premature rupture of the membranes, isoimmunization, fetal growth restriction, and uteroplacental insufficiency (as in diabetes, preeclampsia, or eclampsia)-augmentation of dysfunctional (weak) labor
- stimulation of uterine contraction postpartum → prevents hemorrhage
Contraindications: Oxytocin (Pitocin)
trauma of the mother or fetus due to forced passage through an incompletely dilated cervix, uterine rupture, and compromised fetal oxygenation due to decreased uterine perfusion
Doses: Oxytocin (Pitocin)
Labor: 0.5-2 mU/min (titrate; max dose 20 mU/min)
Post Partum: 10 units at 20-40 mU/min
or 10 IU IM shot
Partial Abortion: 10-20 mU/min
MOA: Carboprost (Hemabate)
PGE2 Receptor Agonist
Induces uterine contractions / expulsion of the placenta
Indications: Carboprost (Hemabate)
Post Partum Hemorrhage
Side Effects/ Contraindications: Carboprost (Hemabate)
Promotes Bronchospasm
Increases CO/PVR/PAP/N&V
Doses: Carboprost (Hemabate)
Post Partum Hemorrhage: 250 mcg IM
- repeat q15min
- 2000mcg max
MOA: Methylergonovine (Methergine)
Alpha-adrenergic, serotonin, and dopaminergic agonist
Prevent/control post-partum hemorrhage via vasoconstriction and highly specific contraction of uterine smooth muscle
Indications: Methylergonovine (Methergine)
Post Partum Hemorrhage
Contraindications: Methylergonovine (Methergine)
Use with caution in pts with PVD, HTN, CAD
Can cause severe HTN, convulsions, stroke, retinal detachment and Pulm edema
Doses: Methylergonovine (Methergine)
IV/IM: 200 mcg
- may be repeated Q2-4 hrs up to 5 doses
