Muscle Relaxants Flashcards
MOA: Succinylcholine
ACh receptor agonist, continuous endplate depolarization;
↑ effects/duration: atypical pseudoChE, hypothermia, reduced ChE activity (liver dz, malnutrition, burns, PG, geriatrics)
CI: Pediatrics (< 8-14yo, unless E)
Metabolism: Pseudo/Plasmacholinesterases
Elimination:
Intubation Dose: Succinylcholine
1 mg/kg
Maintenance Dose: Succinylcholine
0.5-10 mg/min
Half Life: Succinylcholine
47 seconds
MOA: Atracurium
Benzylisoquinoline nAChR antagonist.
Metabolism: Hoffman elimination. Non-specific esterase hydrolysis.
Intubation Dose: Atracurium
0.5 mg/kg
Maintenance Dose: Atracurium
0.25 mg/kg then 0.1 mg/kg
Half Life: Atracurium
20 minutes
MOA: Cisatracurium
Benzylisoquinoline nAChR antagonist.
Metabolism: Hoffman elimination. Non-specific esterase hydrolysis.
Intubation Dose: Cisatracurium
0.1 mg/kg
(no maintenance dose)
MOA: Vecuronium
Aminosteroid. nAChR antagonist.
Intubation Dose: Vecuronium
0.1 mg/kg
Maintenance Dose: Vecuronium
0.04 mg/kg then 0.01 mg/kg
Half Life: Cisatracurium
22 minutes
Half Life: Vecuronium
30-80 minutes
MOA: Rocuronium
Aminosteroid. nAChR antagonist.
Intubation Dose: Rocuronium
0.6-1.2 mg/kg
RSI: 1-1.2 mg/kg
Maintenance Dose: Rocuronium
0.15 mg/kg
Half Life: Rocuronium
1.5-2.5 hours
MOA: Pancuronium
Aminosteroid. nAChR antagonist.
Metabolism: 10-20% liver
Long-Acting
Intubation Dose: Pancuronium
0.1 Mg/kg (0.08-1.8 mg/kg)
Maintenance Dose: Pancuronium
0.04 mg/kg then 0.01 mg/kg
Half Life: Pancuronium
2 Hours
