Swine Flashcards

1
Q

Taxonomy

A

Order: Artiodactyl
Genus: suis
Species: scrofa
38 chromosomes

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2
Q

Lifespan

A

15-25 years

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3
Q

Estrous and gestation

A

E: 18-24 days
G: 110-116

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4
Q

What are newborns given?

A

100-200 mg Fe dextram within 48 hrs of birth to prevent anemia

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5
Q

Nutrition

A

Omnivores
Vitamin E and Selenium
Water

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6
Q

Pre-surgical fasting

A

8-12 hr- stomach and small intestine
48-72 hr- colon

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7
Q

Domestic breeds

A

American Landrace
Yorkshire
Duroc (chester white, hampshire, berkshire, poland china, spotted swine)

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8
Q

Miniature breeds

A

Yucatan
Hanford
Gottingen
Sinclair S-1 (Hormel)

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9
Q

Where should swine be sourced?

A

Purchased from vendor herds brucellosis-free and qualified pseudoraies- negative by the USDA
Vx against erysipelas, lepto, porcine parvo, Bordetella bronchiseptica, P. multocida, E. coli

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10
Q

Why pigs?

A

Close to human size (miniature pigs)
Similar digestive tract, cardio system, physiology and disease progression (metabolic, infectious diseases)
Long lifespan

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11
Q

Salt poisoning

A

Excessive salt (NaCl) → salt toxicity, hypernatremia, water deprivation- sodium ion intoxication
Acute oral lethal dose= 2.2 g/kg

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12
Q

Most common predisposing factor of salt poisoning is _________

A

Water deprivation

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13
Q

Early signs of salt poisoning

A

↑ thirst, pruritus, constipation
Seizures, jerking head, opisthotonos
Comma then die within 2 days

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14
Q

Vitamin E deficiency causes

A

Feeds with high polyunsaturated fatty acids, copper, vit. A or mycotoxins
Grains from soil deficient in selenium and SE antagonists

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15
Q

Prevention and treatment of vitamin E and selenium

A

Injection of Vit. E or selenium
Prevention by supplements

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16
Q

Foot rot (bush foot)

A

Infection of the claw → swollen and painful around coronary band
Progression → enlarged hoof and inflammation
Adverse effects on reproduction

17
Q

What does foot rot come from?

A

Fusiformis bacteria enters the body through sole of foot, split hoof, and cracks

18
Q

Foot rot treatment

A

Footbaths/ soaks: zinc or copper sulfate
Oral therapy: zinc sulfate (21 days)
Penicillin and streptomycin combos

19
Q

Porcine stress syndrome

A

Mutation in calcium-release channel protein in skeletal m. and sarco reticulum
Stressful induce excessive B-adrenergic receptor stimulation

20
Q

Porcine Stress Syndrome breeds

A

Landrace, Yorkshire, Duroc, Petrain, Poland China
Autosomal recessive

21
Q

CS of Porcine stress syndrome

A

Dyspnea, blanched and reddened skin, ↑ body temperature , cyanosis
Then muscle rigidity and cardio. collapse

22
Q

Treatment and prevention for Porcine stress syndrome

A

Dantrolene

23
Q

Litters

A

Multiple per year with reproductive life of 7-8 years

24
Q

Cardiovascular research

A

Atherosclerosis
Myocardial infarction
Congential heart disease
Grafts, stents, interventional devices, CPR

25
Q

GI research

A

Obesity
Hepatic metabolism
Probiotics and gut phys

26
Q

Renal research

A

Hypertension
Transplant and preservation

27
Q

Reproductive research

A

Maternal-fetal interactions
Fetal surgery and microsurgical techniques
OB/GYN surgical procedures

28
Q

Diabetes research

A

Segmental pancreatic transplants
Pancreatectomy models

29
Q

Surgical research

A

Musculoskeletal: bone grafts and implants, temporomandibular joint studies
Integument: plastic surgery , wound healing and skin flaps and grafts

30
Q

Other important research

A

Cell and organ transplant
Stroke
AIDS dimentia
Melanoma
Osteoporosis
Adult respiratory distress syndrone

31
Q

Sinclair S-1 (hormel)- malignant melanoma

A

85% incidence @ 1
Single or multiple skin area tumors
Spontaneous regression (cytotoxic effects, T cells)

32
Q

Concerns of swine for xenotransplantation

A

Acquired zoonoses
Normal flora and environmental contaminants
Viral latency, endogenous retroviruses

33
Q

How are swine used in xenotransplantation

A

Porcine endogenous retrovirus (PERVs)
Hyperacute rejection (HAR) in endothelium
Tolerogenicity: liver > kidney > heart> lung > skin

34
Q

Research uses in integumentary

A

Transdermal absorption
Phototoxicity
Chemical Vesication (blisters)
Contact allergy dermatitis

35
Q

Research uses in interventional radiology

A

Patent ductus arteriosus
Atrial septal defect
Occlusion
Angioplasty
Coronary artery catheterization
Catheter oblation techniques
Stent placement