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1. Avian & Exotics > Mice in Research > Flashcards

Mice in Research Flashcards

1
Q

Taxonomy of mice

A

Order: Rodentia
Genus: Mus
Species: musculus

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2
Q

Outbred stock

A

Created by mating unrelated animals in a closed colony
Swiss webster, ICR and CD-1

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3
Q

Inbred mice

A

Minimum of 20 brother-sister matings
C57L/6, BALB/c, C3H, FVB, 129, DBA

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4
Q

What is significant about mice teeth?

A

Incisors grow throughout life (hypsodant)

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5
Q

Harderian gland

A

Produced secretion that lubricates the globe

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6
Q

How do mice respond to the cold?

A

Non-shivering
Neonates can’t control body temp until past 20 days of age

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7
Q

How do mice respond to heat?

A

Retreat to burrow to cool down

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8
Q

What is the lifespan of mice?

A

1-3 years and 4 years max

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9
Q

How are males distinguished from females?

A

By scrotal sac containing testis and by a longer anogenital distance

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10
Q

Breeding

A
  1. Monogamous
  2. Polygamous/harem= many females 1 male
  3. Rotating system= male moved between cages of females
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11
Q

Behavior

A

Nocturnal

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12
Q

Influences on behavior?

A

Time of day
Genotype
Environment
Pheromones

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13
Q

Environment

A

Temperature- 64-79F
Humidity- 30-70%

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14
Q

Ring tail

A

Tail is thermoregulator –> temps are above 80 and humidity under 40%

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15
Q

Nutrition

A

Fed ab libitum and hard pellets

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16
Q

Common research models

A

Genetic diseases (congenital muscular dystrophy)
Infectious diseases (listeriosis)
Viral infections (Hep C)
Aids
Xenografting

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17
Q

Signs of pain, distress or illness

A

Ruffled fur, hunched posture, red stains around the eyes

18
Q

Mousepox

A

Viral disease transmitted by direct contact and skin abrasions

19
Q

Clinical Signs and diagnosis of mousepox

A

Acute death, dermal rash and conjunctivitis
Serology

20
Q

Pathology of mousepox

A

Intracytoplasmic eosinophilic dermal inclusions
Hepatoceullar necrosis (white foci throughout liver)

21
Q

Treatment of mousepox

A

Depopulation and disinfection

22
Q

Mycoplasmosis

A

Bacterial disease, gram-pos and common in pet and wild populations (resp. tract infection)
Transmitted by direct contact, aerosol and transplacental

23
Q

Clinical signs of Mycoplasmosis

A

Suppurative rhinitis
Otitis media
Chronic pneumonia
Chattering
Dyspnea

24
Q

Pathology of Mycoplasmosis

A

Squamous metaplasia, hyperplasia of submucosal glands, lymphoid infiltration of submucosa, suppurative bronchopneumonia

25
Q

Diagnosis of Mycoplasmosis

A

ELISA, radioimmunosorbent assay, solid- phase radioimmunoassay
Culture (upper resp. tract)

26
Q

Treatment of Mycoplasmosis

A

Tetracyclines (doesn’t eliminate infection)

27
Q

Syphacia Obvelata

A

Common mouse pinworm diagnosed with anal tape impression and PCR
Lifecycle: 11-15 days

28
Q

S. Obvelata eggs

A

Thin-shelled, crescent shape, flattened on one side
Deposited on perianal region
Infective in 6 hours
Airborne dissemination

29
Q

S. Obvelata clinical signs

A

Usually asymptomatic
Heavy infestation:
Rectal prolapse
Intussusception
Enteritis
Fecal impaction

30
Q

S. Obvelata treatment

A

Fenbendazole- medicated feed (9 weeks)
Ivermectin (6 weeks)
Piperazine (2 weeks)

31
Q

Aspiculara tetraptera

A

Eggs are ellipsoidal and asymmetrical
Deposited @ night & excreted in mucous layer covering feces
Infective in 6-7 days

32
Q

Diagnosis and treatment of A. tetraptera

A

Fecal float and cecal and colonic contents (necropsy)
Fendendazole and Ivermectin 1%

33
Q

Hymenolepis nana (dwarf tapeworm)

A

Zoonotic
Asymptomatic but catarrhal enteritis, diarrhea, emaciation,chronic weight loss occurs with heavy infections

34
Q

Diagnosis of Hymenolepis nana

A

Necropsy: worm in small intestine
Fecal float: hexacanth ova
Microscopy: segmented parasites or larve in small intestine

35
Q

Treatment of Hymenolepis nana

A

Niclosamide: 2 treatments @ 7 day intervals

36
Q

Myocoptes musculinus

A

Most common parasitic disease
Occurs in conjunction with Myobia musculi
Inguinal region, abdominal skin and dorsum, superficial dermis

37
Q

Myobia musculi

A

Feed on skin secretions and interstitial fluid
Thermotactic
C57BL mice susceptible

38
Q

Ulcerative Dermatitis

A

Most common in C57BL/6 and C57BL/10
Diet is a contributing factor

39
Q

Clinical signs of ulcetative dermatitis

A

Alopecia, skin ulceration (scarring and disfigurement), pruritus

39
Q

Older mice concerns

A

Chronic renal failure
Amyoid (alzheimers)
Lymphocytic coloal meningitis (zoonotic)

40
Q

Mammary tumors

A

Viral: mouse mammary tumor viruses (MMTV)- C3H, BALB/c and GR strains
Found all over the body

1. Avian & Exotics (14 decks)

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