Surgery- Plastics Flashcards
What type of cells are recruited during the inflammation-sterilization phase of wound healing?
PMNs, Macrophages, Lymphocytes, Fibroblasts
What is the main chemotactic factor for fibroblasts during the proliferation phase?
PDGF
What is the maximum wound strength that can be achieved by a healed wound?
70-80% of original tissueβs tensile strength
This refers to dense collagen matrixes that lack dermal appendages.
Scar
What cells are responsible for wound contracture that persists for 4-6 weeks?
Myofibroblasts
Cytokines: Triggers mitosis of fibroblasts and keratinocytes and induces collagen production. A. IFN-y B. IGF-1 C. PDGF D. TNF-a
B. IGF-1
Cytokines: Also triggers mitosis of fibroblasts and keratinocytes in addition to matrix production. A. IFN-y B. IGF-1 C. TGF-b D. VEGF
C. TGF-b
The minimum tissue oxygen tension requirement for oxygenases to function properly.
~20 mmHg
What is the minimum bacterial load per gram of tissue that prevents wound healing?
10 to the fifth power/g tissue
This chronic disease impairs wound healing due to hypoxia, neuropathy, glycosylated protein malfunction and impaired immune cell localization.
Diabetes mellitus
What systemic factor that inhibits wound healing is due to a relative upregulation of matrix metalloproteinase 2 and 9 thereby decreases collagen synthesis?
Aging
The type of collagen that is the primary form in early phases of wound healing and persists in children, making scars less obvious.
Type III collagen
The type of collagen found in the lens of the eye.
Type IV collagen
The type of collagen that is found in healed wounds.
Type I collagen
The type of wound closure that occurs when tissues are not initially closed or are too extensive to close and instead are closed via tissue proliferation at skin edges.
Secondary closure