Pedia- Endocrine Disorders

Question 1

What is the definitive test for diagnosing hypopituitarism and precocious puberty?

Answer 1

GnRH stimulation test

Question 2

Give the 4 enzyme defects in congenital adrenal hyperlasia.

Answer 2

1. 21-hydroxylase
2. 3-beta-hydroxysteroid dehydrogenase
3. 11-beta-hydroxylase
4. 17,20-lyase

Question 3

What is the most common etiology of precocious puberty in males?

Answer 3

Hamartoma

Question 4

What is the most common acquired cause of hypopituitarism?

Answer 4

Craniopharyngoma

Question 5

Pharmacologic treatment for precocious puberty which halts sexual advancement and maintains open epiphyses

Answer 5

Leuprolide

Question 6

Pharmacologic treatment for salt-losing CAH

Answer 6

Hydrocortisone and Fludrocortisone

Question 6

Hyperthermia, tachycardia and restlessness in a patient with Graves disease suggests

Answer 6

Thyroid storm

Question 7

What is the typical picture of electrolyte imbalance in a patient with CAH?

Answer 7

Hyponatremia, hyperkalemia, acidosis

Question 8

What is the single best test to diagnose Cushing syndrome?

Answer 8

Dexamethasone suppression test

Question 9

Drugs known to cause nephrogenic diabetes insipidus

Answer 9

Lithium, Foscarnet, Amphotericin B, Methicillin and Rifampicin

Question 10

Breast development in the first 2 years of life after which it spontaneously regresses

Answer 10

Premature thelarche

Question 10

RDA of iodine for infants

Answer 10

30 ug/kg/day

Question 11

What is the best test to differentiate central from nephrogenic diabetes insipidus?

Answer 11

Water deprivation test

Question 13

Hyperpituitarism in a child with open epiphysis will manifest as

Answer 13

Gigantism

Question 14

What is the most common cause of thyroid disease in children and adolescents?

Answer 14

Hashimoto’s thyroiditis

Question 15

In the absence of GH in infants, growth velocity typically slows down after _____ so that by age 2 years, height is below 5th percentile.

Answer 15

6-12 months