IM Plat- Hematology

Question 1

What is the definitive treatment for paroxysmal nocturnal hemoglobinuria?

Answer 1

HSC transplant

Question 2

What is the definitive treatment for hereditary spherocytosis?

Answer 2

Splenectomy

Question 3

How does one differentiate iron deficiency anemia from that of a chronic disease?

Answer 3

Fe deficiency: elevated TIBC, low ferritin

Chronic dse: low TIBC, normal to high ferritin

Question 4

What is the most common non-iatrogenic cause of thrombocytopenia?

Answer 4

Infection

Question 5

These are pentalaminar tubules with dilated terminal ends seen in biopsy of skin lesions in patients with Langerhans cell hystiocytosis.

Answer 5

Birbeck granules

Question 6

It is considered as the most important monoclonal gammopathy usually presenting as tumorous masses scattered throughout the skeletal system.

Answer 6

Multiple myeloma

Question 7

All intrinsic hemolytic anemias are lysed in the spleen except ____ and ____.

Answer 7

G6PD and PNH

Question 8

Give the platelet count, bleeding time, PT and PTT picture of a patient with Vitamin K deficiency.

Answer 8

Plt count: normal
BT: normal
PT: prolonged
PTT: prolonged

Question 9

Syndrome of chronic primary hematopoietic failure and attendant pancytopenia.

Answer 9

Aplastic anemia

Question 10

Give the cut offs of Hgb to diagnose anemia in males? females?

Answer 10

Males:

Question 11

Give the cut offs of Hgb to diagnose polycythemia in males? females?

Answer 11

Males: >170 g/L
Females: >150 g/L

Question 12

One unit of pRBC will increase both Hgb and Hct by?

Answer 12

Hgb by 1 g/dL; hct by 3%

Question 13

Spontaneous bleeding is most likely to occur at this platelet level.